ENSG00000179776


Homo sapiens

Features
Gene ID: ENSG00000179776
  
Biological name :CDH5
  
Synonyms : cadherin 5 / CDH5 / P33151
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q21
Gene start: 66366622
Gene end: 66404786
  
Corresponding Affymetrix probe sets: 204677_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458878
Ensembl peptide - ENSP00000479381
Ensembl peptide - ENSP00000461880
Ensembl peptide - ENSP00000344115
Ensembl peptide - ENSP00000455302
Ensembl peptide - ENSP00000455655
Ensembl peptide - ENSP00000456028
Ensembl peptide - ENSP00000456093
NCBI entrez gene - 1003     See in Manteia.
OMIM - 601120
RefSeq - NM_001795
RefSeq - XM_011522801
RefSeq Peptide - NP_001786
swissprot - B4DTR2
swissprot - I3L1J2
swissprot - P33151
swissprot - H3BR64
swissprot - H3BPG1
swissprot - H3BQ82
swissprot - H3BR11
Ensembl - ENSG00000179776
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdh5ENSDARG00000075549Danio rerio
 CDH5ENSGALG00000032349Gallus gallus
 Cdh5ENSMUSG00000031871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000233  Cadherin, cytoplasmic domain
 IPR002126  Cadherin
 IPR015919  Cadherin-like
 IPR020894  Cadherin conserved site
 IPR027397  Catenin binding domain superfamily
 IPR030052  VE-cadherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001955 blood vessel maturation IEA
 biological_processGO:0007043 cell-cell junction assembly IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0034332 adherens junction organization TAS
 biological_processGO:0045766 positive regulation of angiogenesis IGI
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1903142 positive regulation of establishment of endothelial barrier IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISS
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000198561 CTNND1 / O60716 / catenin delta 1  / complex
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / complex
 ENSG00000173801 JUP / P14923 / junction plakoglobin  / complex
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction






 

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