ENSMUSG00000029674


Mus musculus

Features
Gene ID: ENSMUSG00000029674
  
Biological name :Limk1
  
Synonyms : LIM domain kinase 1 / Limk1 / P53668
  
Possible biological names infered from orthology : P53667
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134656039
Gene end: 134688598
  
Corresponding Affymetrix probe sets: 10534324 (MoGene1.0st)   1417627_a_at (Mouse Genome 430 2.0 Array)   1425836_a_at (Mouse Genome 430 2.0 Array)   1456234_at (Mouse Genome 430 2.0 Array)   1458989_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015137
Ensembl peptide - ENSMUSP00000106864
Ensembl peptide - ENSMUSP00000118268
Ensembl peptide - ENSMUSP00000121718
NCBI entrez gene - 16885     See in Manteia.
MGI - MGI:104572
RefSeq - XM_006504396
RefSeq - NM_001305875
RefSeq - NM_010717
RefSeq Peptide - NP_001292804
RefSeq Peptide - NP_034847
swissprot - P53668
swissprot - E9PVB6
swissprot - F6XM68
swissprot - F6PZ73
Ensembl - ENSMUSG00000029674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 limk1aENSDARG00000103467Danio rerio
 limk1bENSDARG00000003022Danio rerio
 LIMK1ENSGALG00000001076Gallus gallus
 LIMK1ENSG00000106683Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Limk2 / O54785 / LIM domain kinase 2 / P53671*ENSMUSG0000002045152
Tesk2 / Q8VCT9 / Dual specificity testis-specific protein kinase 2 / Q96S53* / testis-specific kinase 2*ENSMUSG0000003398521
Tesk1 / O70146 / Dual specificity testis-specific protein kinase 1 / Q15569* / testis-specific kinase 1*ENSMUSG0000002845821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045773 positive regulation of axon extension IGI
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
Sema3A PAK dependent Axon repulsion
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Ptprqtm2Bow/Ptprqtm2Bow
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000029674 Limk1 / P53668 / LIM domain kinase 1 / P53667*  / reaction / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction






 

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