ENSMUSG00000020451


Mus musculus

Features
Gene ID: ENSMUSG00000020451
  
Biological name :Limk2
  
Synonyms : LIM domain kinase 2 / Limk2 / O54785
  
Possible biological names infered from orthology : P53671
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 3344256
Gene end: 3409189
  
Corresponding Affymetrix probe sets: 10383684 (MoGene1.0st)   1418581_a_at (Mouse Genome 430 2.0 Array)   1439896_at (Mouse Genome 430 2.0 Array)   1452060_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099162
Ensembl peptide - ENSMUSP00000099163
Ensembl peptide - ENSMUSP00000099165
Ensembl peptide - ENSMUSP00000105656
NCBI entrez gene - 16886     See in Manteia.
MGI - MGI:1197517
RefSeq - XM_011243666
RefSeq - NM_001034030
RefSeq - NM_010718
RefSeq - NM_173053
RefSeq - XM_006514547
RefSeq - XM_006514548
RefSeq - XM_006514550
RefSeq - XM_006514552
RefSeq Peptide - NP_001029202
RefSeq Peptide - NP_034848
RefSeq Peptide - NP_774958
swissprot - O54785
swissprot - Q5NC03
Ensembl - ENSMUSG00000020451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 limk2ENSDARG00000005104Danio rerio
 LIMK2ENSGALG00000006950Gallus gallus
 LIMK2ENSG00000182541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Limk1 / P53668 / LIM domain kinase 1 / P53667*ENSMUSG0000002967453
Tesk1 / O70146 / Dual specificity testis-specific protein kinase 1 / Q15569* / testis-specific kinase 1*ENSMUSG0000002845821
Tesk2 / Q8VCT9 / Dual specificity testis-specific protein kinase 2 / Q96S53* / testis-specific kinase 2*ENSMUSG0000003398520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0060322 head development IMP
 biological_processGO:0061303 cornea development in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005801 cis-Golgi network IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-Bs/KitW-v
Genetic Background: involves: C57BL/6J

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Limk2Gt(OST80053)Lex/Limk2Gt(OST80053)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0030166 increased inner canthal distance "increased distance between the inner corners (medial canthi) of the eyes where the eyelids meet; may be present without or with ocular hypertelorism (where interpupillary distance is increased)" [HP:0000506, https://en.wikipedia.org/wiki/Telecanthus, PMID:19125427]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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