ENSG00000182541


Homo sapiens

Features
Gene ID: ENSG00000182541
  
Biological name :LIMK2
  
Synonyms : LIM domain kinase 2 / LIMK2 / P53671
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.2
Gene start: 31212239
Gene end: 31280080
  
Corresponding Affymetrix probe sets: 202193_at (Human Genome U133 Plus 2.0 Array)   210582_s_at (Human Genome U133 Plus 2.0 Array)   217475_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330470
Ensembl peptide - ENSP00000388422
Ensembl peptide - ENSP00000384602
Ensembl peptide - ENSP00000339916
Ensembl peptide - ENSP00000332687
NCBI entrez gene - 3985     See in Manteia.
OMIM - 601988
RefSeq - NM_001031801
RefSeq - NM_005569
RefSeq - NM_016733
RefSeq Peptide - NP_057952
RefSeq Peptide - NP_001026971
RefSeq Peptide - NP_005560
swissprot - P53671
swissprot - B5MC51
swissprot - A0A024R1M2
swissprot - A0A024R1H6
swissprot - C9JK61
Ensembl - ENSG00000182541
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 limk2ENSDARG00000005104Danio rerio
 LIMK2ENSGALG00000006950Gallus gallus
 Limk2ENSMUSG00000020451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIMK1 / P53667 / LIM domain kinase 1ENSG0000010668346
TESK1 / Q15569 / testis-specific kinase 1ENSG0000010714020
TESK2 / Q96S53 / testis-specific kinase 2ENSG0000007075918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR008025  CPI-17
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR030476  Pentaxin, conserved site
 IPR036034  PDZ superfamily
 IPR036658  CPI-17 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016310 phosphorylation TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:0061303 cornea development in camera-type eye IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005801 cis-Golgi network IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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