ENSGALG00000001076


Gallus gallus

Features
Gene ID: ENSGALG00000001076
  
Biological name :LIMK1
  
Synonyms : LIM domain kinase 1 / LIMK1 / Q8QFP8
  
Possible biological names infered from orthology : P53667 / P53668
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 776890
Gene end: 785744
  
Corresponding Affymetrix probe sets: Gga.3.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047735
Ensembl peptide - ENSGALP00000039786
NCBI entrez gene - 373922     See in Manteia.
RefSeq - XM_015295657
RefSeq - NM_204131
RefSeq Peptide - NP_989462
swissprot - Q8QFP8
swissprot - A0A1D5P4X1
Ensembl - ENSGALG00000001076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 limk1aENSDARG00000103467Danio rerio
 limk1bENSDARG00000003022Danio rerio
 LIMK1ENSG00000106683Homo sapiens
 Limk1ENSMUSG00000029674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIMK2 / P53666 / LIM domain kinase 2 / O54785* / P53671*ENSGALG0000000695055
TESK1 / testis-specific kinase 1 / O70146* / Q15569* / Dual specificity testis-specific protein kinase 1 *ENSGALG0000002765820
TESK2 / testis-specific kinase 2 / Q8VCT9* / Q96S53* / Dual specificity testis-specific protein kinase 2 *ENSGALG0000001023020
ENSGALG0000003056118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001478  PDZ domain
 IPR001781  Zinc finger, LIM-type
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0051444 negative regulation of ubiquitin-protein transferase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
Sema3A PAK dependent Axon repulsion
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000010175 HSP90AB1 / heat shock cognate protein HSP 90-beta / P08238* / P11499* / Heat shock protein HSP 90-beta * / heat shock protein 90 alpha family class B member 1*  / reaction / complex
 ENSGALG00000001076 LIMK1 / Q8QFP8 / LIM domain kinase 1 / P53667* / P53668*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr