ENSG00000146070


Homo sapiens

Features
Gene ID: ENSG00000146070
  
Biological name :PLA2G7
  
Synonyms : phospholipase A2 group VII / PLA2G7 / Q13093
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p12.3
Gene start: 46704201
Gene end: 46735693
  
Corresponding Affymetrix probe sets: 206214_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274793
Ensembl peptide - ENSP00000445666
NCBI entrez gene - 7941     See in Manteia.
OMIM - 601690
RefSeq - XM_005249408
RefSeq - NM_001168357
RefSeq - NM_005084
RefSeq Peptide - NP_005075
RefSeq Peptide - NP_001161829
swissprot - Q13093
Ensembl - ENSG00000146070
  
Related genetic diseases (OMIM): 147050 - {Atopy, susceptibility to}, 147050
  600807 - {Asthma, susceptibility to}, 600807
  614278 - Platelet-activating factor acetylhydrolase deficiency, 614278
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g7ENSDARG00000003584Danio rerio
 PLA2G7ENSGALG00000016713Gallus gallus
 Pla2g7ENSMUSG00000023913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAFAH2 / Q99487 / platelet activating factor acetylhydrolase 2ENSG0000015800637


Protein motifs (from Interpro)
Interpro ID Name
 IPR005065  Platelet-activating factor acetylhydrolase-like
 IPR016715  Platelet-activating factor acetylhydrolase, eucaryote
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling IDA
 biological_processGO:0034440 lipid oxidation IDA
 biological_processGO:0034441 plasma lipoprotein particle oxidation IDA
 biological_processGO:0046469 platelet activating factor metabolic process IDA
 biological_processGO:0050729 positive regulation of inflammatory response TAS
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0034362 low-density lipoprotein particle IDA
 molecular_functionGO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds TAS
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IDA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0040175 Platelet-activating factor acetylhydrolase deficiency 
Show

 HP:0040178 Increased level of platelet-activating factor 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157017 GHRL / Q9UBU3 / ghrelin and obestatin prepropeptide  / reaction






 

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