ENSDARG00000069307


Danio rerio

Features
Gene ID: ENSDARG00000069307
  
Biological name :pomcb
  
Synonyms : pomcb / proopiomelanocortin b
  
Possible biological names infered from orthology : P01189 / P01193 / POMC / proopiomelanocortin / pro-opiomelanocortin-alpha
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 42968785
Gene end: 42972599
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000091524
NCBI entrez gene - 100034412     See in Manteia.
RefSeq - NM_001083051
RefSeq Peptide - NP_001076520
swissprot - Q5SPP4
ZFIN ID - ZDB-GENE-041014-294
Ensembl - ENSDARG00000069307
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POMCENSGALG00000016600Gallus gallus
 POMCENSG00000115138Homo sapiens
 PomcENSMUSG00000020660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pomca / proopiomelanocortin a / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*ENSDARG0000004313538


Protein motifs (from Interpro)
Interpro ID Name
 IPR001941  Pro-opiomelanocortin
 IPR013531  Pro-opiomelanocortin/corticotropin, ACTH, central region
 IPR013532  Opiodes neuropeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IGI
 biological_processGO:2000852 regulation of corticosterone secretion IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0030141 secretory granule IBA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity IBA


Pathways (from Reactome)
Pathway description
Opioid Signalling
Androgen biosynthesis
Glucocorticoid biosynthesis
G-protein activation
Peptide hormone biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002600 pcsk1 / proprotein convertase subtilisin/kexin type 1 / P29120* / P63239* / Neuroendocrine convertase 1 *  / reaction
 ENSDARG00000021369 mc3r / melanocortin 3 receptor / P33033* / P41968* / Melanocortin receptor 3 *  / reaction / complex
 ENSDARG00000015515 mc4r / B0V1P1 / melanocortin 4 receptor / P32245* / P56450* / Melanocortin receptor 4 *  / reaction / complex
 ENSDARG00000031348 mc5ra / melanocortin 5a receptor / MC5R* / P33032* / melanocortin 5 receptor*  / complex / reaction
 ENSDARG00000054946 mc5rb / melanocortin 5b receptor / MC5R* / P33032* / melanocortin 5 receptor*  / complex / reaction
 ENSDARG00000039434 oprm1 / opioid receptor, mu 1 / P35372* / P42866*  / complex / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / reaction / complex
 ENSDARG00000054949 mc2r / melanocortin 2 receptor / Q01718* / Q64326*  / complex / reaction
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex / reaction






 

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