ENSDARG00000017294


Danio rerio

Features
Gene ID: ENSDARG00000017294
  
Biological name :gnai2b
  
Synonyms : gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
  
Possible biological names infered from orthology : GNAI2 / G protein subunit alpha i2 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899 / P08752
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 53050166
Gene end: 53144336
  
Corresponding Affymetrix probe sets: Dr.20488.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074146
Ensembl peptide - ENSDARP00000128354
NCBI entrez gene - 327650     See in Manteia.
swissprot - F1QDT7
swissprot - Q7ZWI5
swissprot - X1WDQ5
ZFIN ID - ZDB-GENE-030131-5861
Ensembl - ENSDARG00000017294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAI2ENSGALG00000035645Gallus gallus
 GNAI2ENSG00000114353Homo sapiens
 Gnai2ENSMUSG00000032562Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001817489
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSDARG0000002164786
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...ENSDARG0000003064483
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide aENSDARG0000004476082
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000001667669
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000003605866
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...ENSDARG0000004419965
GNAZ / G protein subunit alpha z / P19086*ENSDARG0000009984464
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...ENSDARG0000004252963
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*ENSDARG0000001148751
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)ENSDARG0000001000250
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)ENSDARG0000005332650
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*ENSDARG0000002501349
gnav1 / guanine nucleotide binding protein (G protein) alpha v1ENSDARG0000004300648
gna14 / guanine nucleotide binding protein (G protein), alpha 14ENSDARG0000003517847
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...ENSDARG0000001636446
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...ENSDARG0000005665444
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*ENSDARG0000003792440
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*ENSDARG0000002582639
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*ENSDARG0000007376539


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001973 adenosine receptor signaling pathway IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000069945 p2ry12 / purinergic receptor P2Y12 / Q9CPV9* / Q9H244* / purinergic receptor P2Y, G-protein coupled 12*  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / reaction / complex






 

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