ENSDARG00000037924


Danio rerio

Features
Gene ID: ENSDARG00000037924
  
Biological name :gna13b
  
Synonyms : gna13b / guanine nucleotide binding protein (G protein), alpha 13b
  
Possible biological names infered from orthology : GNA13 / G protein subunit alpha 13 / guanine nucleotide binding protein, alpha 13 / P27601 / Q14344
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 36332579
Gene end: 36364903
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000036006
NCBI entrez gene - 336333     See in Manteia.
RefSeq - NM_001013263
RefSeq Peptide - NP_001013281
swissprot - F1QHJ3
ZFIN ID - ZDB-GENE-030131-8277
Ensembl - ENSDARG00000037924
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNA13ENSGALG00000036028Gallus gallus
 GNA13ENSG00000120063Homo sapiens
 Gna13ENSMUSG00000020611Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*ENSDARG0000007376581
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*ENSDARG0000002582660
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)ENSDARG0000001000245
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)ENSDARG0000005332645
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*ENSDARG0000001148745
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*ENSDARG0000002501344
gna14 / guanine nucleotide binding protein (G protein), alpha 14ENSDARG0000003517842
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...ENSDARG0000001636442
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000001667640
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...ENSDARG0000005665440
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000003605839
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001729438
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...ENSDARG0000003064438
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide aENSDARG0000004476038
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSDARG0000002164737
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...ENSDARG0000004419937
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...ENSDARG0000004252937
GNAZ / G protein subunit alpha z / P19086*ENSDARG0000009984437
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001817437
gnav1 / guanine nucleotide binding protein (G protein) alpha v1ENSDARG0000004300636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000469  G-protein alpha subunit, group 12/13
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0007492 endoderm development IGI
 biological_processGO:0009826 unidimensional cell growth IGI
 biological_processGO:0014003 oligodendrocyte development IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0031584 activation of phospholipase D activity IBA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IGI
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0043149 stress fiber assembly IMP
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IGI
 biological_processGO:0060026 convergent extension IGI
 biological_processGO:0060973 cell migration involved in heart development IGI
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0031526 brush border membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IBA
 molecular_functionGO:0031752 D5 dopamine receptor binding IBA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta shortened , abnormal
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 ZFA:0000017 endoderm endoderm anterior region increased width , abnormal
endoderm anterior region perforate , abnormal
endoderm antero-medial region decreased object quality , abnormal
endoderm cell migration process quality , abnormal
endoderm cell migration decreased occurrence , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000094 blood island blood island apoptotic process increased occurrence , abnormal
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 ZFA:0000114 heart heart duplicated , abnormal
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 ZFA:0000360 heart tube heart tube split bilaterally , abnormal
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 ZFA:0001058 caudal fin caudal fin blistered , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel absent , abnormal
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 ZFA:0001319 myocardium myocardium unfused from myocardium , abnormal
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 ZFA:0001320 endocardium endocardium unfused from endocardium , abnormal
endocardium structure , abnormal
endocardium disorganized , abnormal
endocardium loose , abnormal
endocardium mislocalised , abnormal
endocardium cardioblast migration process quality , abnormal
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 ZFA:0005489 endocardial precursor endocardial precursor anatomical region spatial pattern , abnormal
endocardial precursor mislocalised , abnormal
endocardial precursor cardioblast migration to the midline involved in heart field formation decreased occurrence , abnormal
endocardial precursor anatomical side spatial pattern , abnormal
endocardial precursor fibronectin fibril disoriented , abnormal
endocardial precursor fibronectin fibril disorganized , abnormal
endocardial precursor fibronectin fibril organization decreased occurrence , abnormal
endocardial precursor cell leading edge decreased amount , abnormal
endocardial precursor cell trailing edge increased amount , abnormal
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 ZFA:0005490 myocardial precursor myocardial precursor mislocalised laterally , abnormal
myocardial precursor anatomical region spatial pattern , abnormal
myocardial precursor cardioblast migration to the midline involved in heart field formation decreased occurrence , abnormal
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 ZFA:0009044 blood cell blood cell absent , abnormal
blood cell decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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