Manteia

ENSDARG00000018174

Danio rerio

Features

Gene ID:	ENSDARG00000018174

Biological name :	gnai2a

Synonyms :	gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a

Possible biological names infered from orthology :	GNAI2 / G protein subunit alpha i2 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899 / P08752

Species:	Danio rerio

Chr. number:	11
Strand:	1
Band:
Gene start:	34921492
Gene end:	35042194

Corresponding Affymetrix probe sets:	Dr.26521.1.A1_at (Zebrafish Array) NM_001001818_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000106050 NCBI entrez gene - 336421 See in Manteia. RefSeq - NM_001001818 RefSeq Peptide - NP_001001818 swissprot - Q6TNT8 ZFIN ID - ZDB-GENE-030131-8365 Ensembl - ENSDARG00000018174

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GNAI2	ENSGALG00000035645	Gallus gallus
GNAI2	ENSG00000114353	Homo sapiens
Gnai2	ENSMUSG00000032562	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...	ENSDARG00000017294	89
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ENSDARG00000021647	84
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ENSDARG00000044760	81
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...	ENSDARG00000030644	81
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...	ENSDARG00000016676	67
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...	ENSDARG00000036058	65
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...	ENSDARG00000042529	64
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...	ENSDARG00000044199	64
GNAZ / G protein subunit alpha z / P19086*	ENSDARG00000099844	62
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*	ENSDARG00000011487	50
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)	ENSDARG00000053326	48
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)	ENSDARG00000010002	48
gnav1 / guanine nucleotide binding protein (G protein) alpha v1	ENSDARG00000043006	47
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*	ENSDARG00000025013	47
gna14 / guanine nucleotide binding protein (G protein), alpha 14	ENSDARG00000035178	46
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...	ENSDARG00000016364	45
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...	ENSDARG00000056654	42
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*	ENSDARG00000025826	39
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*	ENSDARG00000037924	39
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*	ENSDARG00000073765	39

Protein motifs (from Interpro)

Interpro ID	Name
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408	G-protein alpha subunit, group I
IPR011025	G protein alpha subunit, helical insertion
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001973	adenosine receptor signaling pathway	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0007214	gamma-aminobutyric acid signaling pathway	IBA
cellular_component	GO:0005834	heterotrimeric G-protein complex	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IBA
molecular_function	GO:0003924	GTPase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	IBA
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0019001	guanyl nucleotide binding	IEA
molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA

Pathways (from Reactome)

Pathway description

PLC beta mediated events

Adenylate cyclase inhibitory pathway

G-protein activation

ADP signalling through P2Y purinoceptor 12

Adrenaline,noradrenaline inhibits insulin secretion

G alpha (i) signalling events

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000056831	gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*	/ complex / reaction
ENSDARG00000069945	p2ry12 / purinergic receptor P2Y12 / Q9CPV9* / Q9H244* / purinergic receptor P2Y, G-protein coupled 12*	/ complex / reaction
ENSDARG00000090454	gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*	/ reaction / complex
ENSDARG00000104372	gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr