ENSDARG00000060012


Danio rerio

Features
Gene ID: ENSDARG00000060012
  
Biological name :f2r
  
Synonyms : coagulation factor II (thrombin) receptor / f2r
  
Possible biological names infered from orthology : P25116 / P30558 / Proteinase-activated receptor 1
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 46196147
Gene end: 46198034
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000078547
NCBI entrez gene - 558477     See in Manteia.
RefSeq - NM_001114846
RefSeq Peptide - NP_001108318
swissprot - A2BIP6
ZFIN ID - ZDB-GENE-060526-30
Ensembl - ENSDARG00000060012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F2RENSGALG00000014983Gallus gallus
 F2RENSG00000181104Homo sapiens
 F2rENSMUSG00000048376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-163m14.6ENSDARG0000009004137
si:dkey-163m14.4ENSDARG0000008746937
zgc:171965ENSDARG0000007763836
si:dkey-163m14.7ENSDARG0000008623636
si:dkey-163m14.2ENSDARG0000005950735
si:dkey-163m14.10ENSDARG0000008626235
f2rl1.2 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *ENSDARG0000007754030
f2rl1.1 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *ENSDARG0000006885627
p2ry8 / P2Y receptor family member 8 / Q86VZ1*ENSDARG0000005556026
F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*ENSDARG0000007939925
CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*ENSDARG0000007947223
f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*ENSDARG0000009052423
gpr4 / G protein-coupled receptor 4 / P46093* / Q8BUD0*ENSDARG0000007947921
si:dkey-211g8.6 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (gen...ENSDARG0000006308819
si:dkey-211g8.7 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (gen...ENSDARG0000005853519
gpr132b / G protein-coupled receptor 132b / Q9Z282* / GPR132* / Q9UNW8* / G protein-coupled receptor 132*ENSDARG0000010354019
si:dkey-165a24.9ENSDARG0000009005219
gpr132a / G protein-coupled receptor 132a / Q9Z282* / GPR132* / Q9UNW8* / G protein-coupled receptor 132*ENSDARG0000002149718
si:ch211-231m23.4 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (g...ENSDARG0000004129218
GPR68 / G protein-coupled receptor 68 / Q15743*ENSDARG0000005371117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000935  Thrombin receptor
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0072358 cardiovascular system development IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1902037 negative regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0015057 thrombin-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood increased accumulation blood island , abnormal
blood increased accumulation caudal vein , abnormal
blood increased accumulation post-vent region , abnormal
blood increased accumulation vasculature , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta decreased size , abnormal
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 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000128 midbrain midbrain hemorrhagic , abnormal
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 ZFA:0000180 caudal vein caudal vein disorganized , abnormal
caudal vein dilated , abnormal
caudal vein malformed , abnormal
caudal vein functionality , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein functionality , abnormal
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 ZFA:0000547 mouth mouth structure , abnormal
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 ZFA:0001117 post-vent region post-vent region bent , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel collapsed , abnormal
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 ZFA:0005020 central artery central artery hemorrhagic , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell increased amount , abnormal
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 ZFA:0005094 optic choroid vascular plexus optic choroid vascular plexus hemorrhagic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000025826 gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*  / complex / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / reaction / complex
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / reaction
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / reaction / complex
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / reaction
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / complex / reaction
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / reaction / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / reaction / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction






 

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