ENSG00000161714


Homo sapiens

Features
Gene ID: ENSG00000161714
  
Biological name :PLCD3
  
Synonyms : phospholipase C delta 3 / PLCD3 / Q8N3E9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 45108967
Gene end: 45133354
  
Corresponding Affymetrix probe sets: 1552476_s_at (Human Genome U133 Plus 2.0 Array)   234971_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440378
Ensembl peptide - ENSP00000467800
Ensembl peptide - ENSP00000479636
Ensembl peptide - ENSP00000443079
NCBI entrez gene - 113026     See in Manteia.
OMIM - 608795
RefSeq - NM_133373
RefSeq Peptide - NP_588614
swissprot - Q8N3E9
swissprot - F5GXC1
swissprot - H0YGF8
swissprot - K7EQF2
Ensembl - ENSG00000161714
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5D6R3ENSDARG00000052957Danio rerio
 plcd3bENSDARG00000079572Danio rerio
 PLCD3ENSGALG00000045212Gallus gallus
 Plcd3ENSMUSG00000020937Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLCD1 / P51178 / phospholipase C delta 1ENSG0000018709148
PLCD4 / Q9BRC7 / phospholipase C delta 4ENSG0000011555646
PLCH2 / O75038 / phospholipase C eta 2ENSG0000014952736
PLCH1 / Q4KWH8 / phospholipase C eta 1ENSG0000011480535
PLCL2 / Q9UPR0 / phospholipase C like 2ENSG0000015482234
PLCL1 / Q15111 / phospholipase C like 1 (inactive)ENSG0000011589633
PLCB2 / Q00722 / phospholipase C beta 2ENSG0000013784130
PLCZ1 / Q86YW0 / phospholipase C zeta 1ENSG0000013915130
PLCB3 / Q01970 / phospholipase C beta 3ENSG0000014978230
PLCB4 / Q15147 / phospholipase C beta 4ENSG0000010133330
PLCB1 / Q9NQ66 / phospholipase C beta 1ENSG0000018262128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028406  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043647 inositol phosphate metabolic process TAS
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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