ENSG00000171189


Homo sapiens

Features
Gene ID: ENSG00000171189
  
Biological name :GRIK1
  
Synonyms : glutamate ionotropic receptor kainate type subunit 1 / GRIK1 / P39086
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q21.3
Gene start: 29536933
Gene end: 29940033
  
Corresponding Affymetrix probe sets: 207242_s_at (Human Genome U133 Plus 2.0 Array)   214611_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373777
Ensembl peptide - ENSP00000373776
Ensembl peptide - ENSP00000382791
Ensembl peptide - ENSP00000382798
Ensembl peptide - ENSP00000382797
Ensembl peptide - ENSP00000382793
Ensembl peptide - ENSP00000327687
NCBI entrez gene - 2897     See in Manteia.
OMIM - 138245
RefSeq - XM_006723991
RefSeq - NM_000830
RefSeq - NM_001320616
RefSeq - NM_001320618
RefSeq - NM_001320621
RefSeq - NM_001330993
RefSeq - NM_175611
RefSeq - XM_005260942
RefSeq - XM_005260944
RefSeq Peptide - NP_001307547
RefSeq Peptide - NP_000821
RefSeq Peptide - NP_001307550
RefSeq Peptide - NP_001317922
RefSeq Peptide - NP_001317923
RefSeq Peptide - NP_783300
RefSeq Peptide - NP_001307545
swissprot - E7EPZ0
swissprot - E7ENK3
swissprot - E9PD61
swissprot - P39086
swissprot - E7EPY9
swissprot - H7BYG7
Ensembl - ENSG00000171189
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grik1aENSDARG00000069139Danio rerio
 grik1bENSDARG00000040627Danio rerio
 GRIK1ENSGALG00000015835Gallus gallus
 Grik1ENSMUSG00000022935Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2ENSG0000016441874
GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3ENSG0000016387370
GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5ENSG0000010573740
GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4ENSG0000014940339
GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2ENSG0000012025136
GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3ENSG0000012567536
GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1ENSG0000015551136
GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4ENSG0000015257835
GRID1 / Q9ULK0 / glutamate ionotropic receptor delta type subunit 1ENSG0000018277127
GRID2 / O43424 / glutamate ionotropic receptor delta type subunit 2ENSG0000015220826
GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1ENSG0000017688420
GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2AENSG0000018345420
GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2CENSG0000016150919
GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2BENSG0000027307919
GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2DENSG0000010546419
GRIN3A / Q8TCU5 / glutamate ionotropic receptor NMDA type subunit 3AENSG0000019878518
GRIN3B / O60391 / glutamate ionotropic receptor NMDA type subunit 3BENSG0000011603218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007215 glutamate receptor signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic TAS
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity TAS
 molecular_functionGO:0015277 kainate selective glutamate receptor activity IDA


Pathways (from Reactome)
Pathway description
Activation of Na-permeable kainate receptors
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex
 ENSG00000105737 GRIK5 / Q16478 / glutamate ionotropic receptor kainate type subunit 5  / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex
 ENSG00000164418 GRIK2 / Q13002 / glutamate ionotropic receptor kainate type subunit 2  / reaction / complex
 ENSG00000163873 GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3  / complex
 ENSG00000171189 GRIK1 / P39086 / glutamate ionotropic receptor kainate type subunit 1  / reaction / complex
 ENSG00000149403 GRIK4 / Q16099 / glutamate ionotropic receptor kainate type subunit 4  / complex






 

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