ENSGALG00000014977


Gallus gallus

Features
Gene ID: ENSGALG00000014977
  
Biological name :GSK3B
  
Synonyms : glycogen synthase kinase 3 beta / GSK3B
  
Possible biological names infered from orthology : P49841 / Q9WV60
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 80014156
Gene end: 80099885
  
Corresponding Affymetrix probe sets: Gga.7650.1.S1_at (Chicken Array)   GgaAffx.24561.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000029838
NCBI entrez gene - 418335     See in Manteia.
RefSeq - XM_004938179
RefSeq - XM_015294935
RefSeq - XM_416557
swissprot - F1NPL8
Ensembl - ENSGALG00000014977
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsk3bENSDARG00000017803Danio rerio
 si:dkeyp-80c12.7ENSDARG00000052468Danio rerio
 GSK3BENSG00000082701Homo sapiens
 Gsk3bENSMUSG00000022812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR033573  Glycogen synthase kinase-3 beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0010822 positive regulation of mitochondrion organization IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032886 regulation of microtubule-based process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071109 superior temporal gyrus development IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1904781 positive regulation of protein localization to centrosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0034452 dynactin binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
GLI3 is processed to GLI3R by the proteasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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