ENSG00000181274


Homo sapiens

Features
Gene ID: ENSG00000181274
  
Biological name :FRAT2
  
Synonyms : FRAT2 / FRAT2, WNT signaling pathway regulator / O75474
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 97332497
Gene end: 97334709
  
Corresponding Affymetrix probe sets: 209864_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360058
NCBI entrez gene - 23401     See in Manteia.
OMIM - 605006
RefSeq - NM_012083
RefSeq Peptide - NP_036215
swissprot - O75474
Ensembl - ENSG00000181274
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Frat2ENSMUSG00000047604Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FRAT1 / Q92837 / FRAT1, WNT signaling pathway regulatorENSG0000016587979


Protein motifs (from Interpro)
Interpro ID Name
 IPR008014  Glycogen synthase kinase-3 binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development NAS
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / complex / reaction






 

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