ENSG00000061492


Homo sapiens

Features
Gene ID: ENSG00000061492
  
Biological name :WNT8A
  
Synonyms : Q9H1J5 / WNT8A / Wnt family member 8A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.2
Gene start: 138083892
Gene end: 138092365
  
Corresponding Affymetrix probe sets: 224259_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424809
Ensembl peptide - ENSP00000426653
Ensembl peptide - ENSP00000354726
Ensembl peptide - ENSP00000381739
NCBI entrez gene - 7478     See in Manteia.
OMIM - 606360
RefSeq - XM_017009825
RefSeq - NM_001300938
RefSeq - NM_001300939
RefSeq - NM_058244
RefSeq - XM_011543625
RefSeq - XM_017009824
RefSeq Peptide - NP_001287868
RefSeq Peptide - NP_490645
RefSeq Peptide - NP_001287867
swissprot - D6RF94
swissprot - Q9H1J5
swissprot - D6RF47
Ensembl - ENSG00000061492
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt8aENSDARG00000078507Danio rerio
 wnt8aENSDARG00000052910Danio rerio
 WNT8AENSGALG00000037494Gallus gallus
 Wnt8aENSMUSG00000012282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT8B / Q93098 / Wnt family member 8BENSG0000007529060
Q9GZT5 / WNT10A / Wnt family member 10AENSG0000013592532
WNT9B / O14905 / Wnt family member 9BENSG0000015895531
O00744 / WNT10B / Wnt family member 10BENSG0000016988430
WNT9A / O14904 / Wnt family member 9AENSG0000014381630


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013301  Wnt-8 protein
 IPR018161  Wnt protein, conserved site
 IPR034312  Protein Wnt-8A/8C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0003002 regionalization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0009949 polarity specification of anterior/posterior axis IEA
 biological_processGO:0010085 polarity specification of proximal/distal axis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014034 neural crest cell fate commitment ISS
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0032526 response to retinoic acid NAS
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0044324 regulation of transcription involved in anterior/posterior axis specification ISS
 biological_processGO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation ISS
 biological_processGO:0048561 establishment of animal organ orientation IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEP
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA
 molecular_functionGO:0048018 receptor ligand activity IDA


Pathways (from Reactome)
Pathway description
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / complex / reaction
 ENSG00000103126 AXIN1 / O15169  / reaction / complex
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / complex / reaction
 ENSG00000157240 FZD1 / Q9UP38 / frizzled class receptor 1  / reaction / complex
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / reaction / complex
 ENSG00000180340 FZD2 / Q14332 / frizzled class receptor 2  / complex / reaction
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / reaction / complex






 

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