ENSDARG00000078507


Danio rerio

Features
Gene ID: ENSDARG00000078507
  
Biological name :wnt8a
  
Synonyms : wingless-type MMTV integration site family, member 8a / wnt8a
  
Possible biological names infered from orthology : Q64527 / Q9H1J5 / Wnt family member 8A
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 34495216
Gene end: 34497724
  
Corresponding Affymetrix probe sets: Dr.309.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000119476
swissprot - B8A4J5
ZFIN ID - ZDB-GENE-980526-332
Ensembl - ENSDARG00000078507
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WNT8AENSGALG00000037494Gallus gallus
 WNT8AENSG00000061492Homo sapiens
 Wnt8aENSMUSG00000012282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wnt8a / wingless-type MMTV integration site family, member 8a / Q64527* / Q9H1J5* / Wnt family member 8A*ENSDARG0000005291070
wnt8b / wingless-type MMTV integration site family, member 8b / Q93098* / Wnt family member 8B*ENSDARG0000000691163
wnt10a / wingless-type MMTV integration site family, member 10a / Q9GZT5* / Wnt family member 10A*ENSDARG0000001715535
wnt10b / wingless-type MMTV integration site family, member 10b / O00744* / P48614* / Wnt family member 10B*ENSDARG0000004092530
wnt9b / wingless-type MMTV integration site family, member 9B / O14905* / O35468* / Wnt family member 9B*ENSDARG0000003788928
wnt9a / wingless-type MMTV integration site family, member 9A / O14904* / Wnt family member 9A*ENSDARG0000006343727


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR013301  Wnt-8 protein
 IPR034312  Protein Wnt-8A/8C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
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 ZFA:0000008 brain brain poorly differentiated , abnormal
brain decreased length , abnormal
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 ZFA:0000038 margin margin decreased distribution , abnormal
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 ZFA:0000041 mesoderm mesoderm posterior region increased length , abnormal
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 ZFA:0000063 presumptive neural plate presumptive neural plate wholly anterioralized , abnormal
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 ZFA:0000071 shield shield increased width , abnormal
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 ZFA:0000077 tail bud tail bud morphology , abnormal
tail bud bent , abnormal
tail bud decreased length , abnormal
tail bud protruding , abnormal
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 ZFA:0000079 telencephalon telencephalon increased size , abnormal
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 ZFA:0000083 ventral mesoderm ventral mesoderm mislocalised , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
axis mislocalised posteriorly , abnormal
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 ZFA:0000106 extension extension increased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye increased size , abnormal
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 ZFA:0000109 forebrain forebrain apoptotic , abnormal
forebrain prominent , abnormal
forebrain distended , abnormal
forebrain increased size , abnormal
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 ZFA:0000128 midbrain midbrain decreased size , abnormal
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 ZFA:0000131 neural keel neural keel wholly anterioralized , abnormal
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 ZFA:0000135 notochord notochord structure , abnormal
notochord increased width , abnormal
notochord truncated , abnormal
notochord undulate , abnormal
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 ZFA:0000151 pronephros pronephros amount , ameliorated
pronephros decreased amount , abnormal
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 ZFA:0000155 somite somite decreased amount , abnormal
somite structure , abnormal
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 ZFA:0000571 presumptive telencephalon presumptive telencephalon increased distribution , abnormal
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 ZFA:0000938 central canal central canal dilated , abnormal
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 ZFA:0001058 caudal fin caudal fin morphology , abnormal
caudal fin absent , abnormal
caudal fin posterior region absent , abnormal
caudal fin ventral region absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism wholly dorsalized , abnormal
whole organism dead , abnormal
whole organism wholly anterioralized , abnormal
whole organism shape , abnormal
whole organism decreased size , abnormal
whole organism absent , abnormal
whole organism viability , abnormal
whole organism wholly ventralized , abnormal
whole organism posterior region absent , abnormal
whole organism dorsal region increased distribution , abnormal
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 ZFA:0001114 head head increased size , abnormal
head decreased size , abnormal
head malformed , abnormal
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 ZFA:0001115 trunk trunk mesoderm decreased size , abnormal
trunk decreased length , abnormal
trunk posterior region absent , abnormal
trunk aplastic , abnormal
trunk decreased size , abnormal
trunk ventral region absent , abnormal
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 ZFA:0001117 post-vent region post-vent region mesoderm decreased size , abnormal
post-vent region decreased length , abnormal
post-vent region truncated , abnormal
post-vent region kinked , abnormal
post-vent region has fewer parts of type somite , abnormal
post-vent region decreased size , abnormal
post-vent region aplastic , abnormal
post-vent region curved ventral , abnormal
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 ZFA:0001204 axial mesoderm axial mesoderm increased amount , abnormal
axial mesoderm increased distribution , abnormal
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 ZFA:0001377 presumptive mesoderm presumptive mesoderm wholly dorsalized , abnormal
presumptive mesoderm nucleus absent , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule distal region decreased distribution , abnormal
pronephric tubule distal region decreased amount , abnormal
pronephric tubule cell increased distance pronephric tubule cell, abnormal
pronephric tubule amount , ameliorated
pronephric tubule decreased amount , abnormal
pronephric tubule proximal region has number of cell , ameliorated
pronephric tubule proximal region has fewer parts of type cell , abnormal
pronephric tubule cell proliferation decreased occurrence , abnormal
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 ZFA:0001714 presumptive ventral mesoderm presumptive ventral mesoderm decreased amount , abnormal
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 ZFA:0009021 common myeloid progenitor common myeloid progenitor decreased amount , abnormal
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 ZFA:0009137 ectodermal cell ectodermal cell nucleus absent , abnormal
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 ZFA:0009165 neural crest cell neural crest cell morphology , abnormal
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 ZFA:0009325 erythroid lineage cell erythroid lineage cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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