ENSG00000105723


Homo sapiens

Features
Gene ID: ENSG00000105723
  
Biological name :GSK3A
  
Synonyms : glycogen synthase kinase 3 alpha / GSK3A / P49840
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 42230186
Gene end: 42242625
  
Corresponding Affymetrix probe sets: 202210_x_at (Human Genome U133 Plus 2.0 Array)   632_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000222330
Ensembl peptide - ENSP00000412663
Ensembl peptide - ENSP00000381301
NCBI entrez gene - 2931     See in Manteia.
OMIM - 606784
RefSeq - NM_019884
RefSeq Peptide - NP_063937
swissprot - A8MT37
swissprot - A0A024R0L5
swissprot - P49840
Ensembl - ENSG00000105723
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsk3aaENSDARG00000029501Danio rerio
 gsk3abENSDARG00000015681Danio rerio
 Gsk3aENSMUSG00000057177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSK3B / P49841 / glycogen synthase kinase 3 betaENSG0000008270166
AC006486.1ENSG0000026864333


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure ISS
 biological_processGO:0003214 cardiac left ventricle morphogenesis ISS
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007212 dopamine receptor signaling pathway NAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010905 negative regulation of UDP-glucose catabolic process IC
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0032007 negative regulation of TOR signaling ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0036016 cellular response to interleukin-3 ISS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0044027 hypermethylation of CpG island IEA
 biological_processGO:0045719 negative regulation of glycogen biosynthetic process TAS
 biological_processGO:0045732 positive regulation of protein catabolic process NAS
 biological_processGO:0045823 positive regulation of heart contraction ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046325 negative regulation of glucose import IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0060079 excitatory postsynaptic potential NAS
 biological_processGO:0061052 negative regulation of cell growth involved in cardiac muscle cell development ISS
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISS
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand ISS
 biological_processGO:0106071 positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
 biological_processGO:1902004 positive regulation of amyloid-beta formation IMP
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate IMP
 biological_processGO:2000077 negative regulation of type B pancreatic cell development TAS
 biological_processGO:2000171 negative regulation of dendrite development IEA
 biological_processGO:2000466 negative regulation of glycogen (starch) synthase activity TAS
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030877 beta-catenin destruction complex NAS
 cellular_componentGO:0043025 neuronal cell body NAS
 cellular_componentGO:0097440 apical dendrite NAS
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:1990635 proximal dendrite NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI
 molecular_functionGO:0050321 tau-protein kinase activity TAS


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction






 

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