ENSMUSG00000057177


Mus musculus

Features
Gene ID: ENSMUSG00000057177
  
Biological name :Gsk3a
  
Synonyms : Glycogen synthase kinase-3 alpha / Gsk3a / Q2NL51
  
Possible biological names infered from orthology : P49840
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25228258
Gene end: 25237851
  
Corresponding Affymetrix probe sets: 10560993 (MoGene1.0st)   1435638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071654
Ensembl peptide - ENSMUSP00000104049
NCBI entrez gene - 606496     See in Manteia.
MGI - MGI:2152453
RefSeq - XM_006540259
RefSeq - NM_001031667
RefSeq - XM_006540258
RefSeq Peptide - NP_001026837
swissprot - Q2NL51
swissprot - D3Z7E5
Ensembl - ENSMUSG00000057177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsk3aaENSDARG00000029501Danio rerio
 gsk3abENSDARG00000015681Danio rerio
 GSK3AENSG00000105723Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*ENSMUSG0000002281265


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0003214 cardiac left ventricle morphogenesis IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IGI
 biological_processGO:0018105 peptidyl-serine phosphorylation IGI
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0036016 cellular response to interleukin-3 IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0044027 hypermethylation of CpG island IMP
 biological_processGO:0045823 positive regulation of heart contraction IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0061052 negative regulation of cell growth involved in cardiac muscle cell development IMP
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071879 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IGI
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:0106071 positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate IEA
 biological_processGO:2000171 negative regulation of dendrite development IEA
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3btm1Grc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Gsk3atm1Jrw/Gsk3atm1Jrw,Gsk3btm2Jrw/Gsk3btm2Jrw
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gsk3atm1a(EUCOMM)Hmgu/Gsk3a+
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Gsk3atm1a(EUCOMM)Hmgu/Gsk3a+
Genetic Background: Not Specified

Allelic Composition: Gsk3atm1a(EUCOMM)Hmgu/Gsk3atm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hpgdtm1Ljm/Hpgd+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003064 decreased coping response "reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Frem1tm1Ksek/Frem1tm1Ksek
Genetic Background: involves: 129

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Hpgdtm1Ljm/Hpgd+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hpgdtm1Ljm/Hpgd+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gys1tm1.1Arte/Gys1+
Genetic Background: involves: C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hpgdtm1Ljm/Hpgd+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ftotm1a(EUCOMM)Wtsi/Ftotm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Ftotm1a(EUCOMM)Wtsi/Wtsi

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gsk3atm1.1Jrw/Gsk3atm1.1Jrw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0030431 wide metopic suture "an abnormally increased width of the metopic suture for age-related norms" [MGI:anna]
Show

Allelic Composition: Nle1rs2820949-G/Nle1rs2820949-G
Genetic Background: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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