ENSG00000085741


Homo sapiens

Features
Gene ID: ENSG00000085741
  
Biological name :WNT11
  
Synonyms : O96014 / WNT11 / Wnt family member 11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.5
Gene start: 76186325
Gene end: 76210736
  
Corresponding Affymetrix probe sets: 206737_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000325526
Ensembl peptide - ENSP00000436140
Ensembl peptide - ENSP00000483229
NCBI entrez gene - 7481     See in Manteia.
OMIM - 603699
RefSeq - XM_011545240
RefSeq - NM_004626
RefSeq - XM_005274231
RefSeq - XM_011545238
RefSeq - XM_011545239
RefSeq Peptide - NP_004617
swissprot - O96014
swissprot - H8YS97
Ensembl - ENSG00000085741
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt11rENSDARG00000014796Danio rerio
 WNT11ENSGALG00000000839Gallus gallus
 Wnt11ENSMUSG00000015957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT4 / P56705 / Wnt family member 4ENSG0000016255238
WNT5B / Q9H1J7 / Wnt family member 5BENSG0000011118638
WNT5A / P41221 / Wnt family member 5AENSG0000011425138
WNT2B / Q93097 / Wnt family member 2BENSG0000013424537
WNT7A / O00755 / Wnt family member 7AENSG0000015476436
WNT3 / P56703 / Wnt family member 3ENSG0000010837936
WNT3A / P56704 / Wnt family member 3AENSG0000015434235
WNT16 / Q9UBV4 / Wnt family member 16ENSG0000000274535
WNT6 / Q9Y6F9 / Wnt family member 6ENSG0000011559635
WNT2 / P09544 / Wnt family member 2ENSG0000010598935
WNT1 / P04628 / Wnt family member 1ENSG0000012508434
WNT7B / P56706 / Wnt family member 7BENSG0000018806434


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026536  Wnt-11 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IEA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030325 adrenal gland development IEP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032915 positive regulation of transforming growth factor beta2 production IEA
 biological_processGO:0034394 protein localization to cell surface IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045199 maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048341 paraxial mesoderm formation IEA
 biological_processGO:0048570 notochord morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEP
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060028 convergent extension involved in axis elongation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0060197 cloacal septation IEP
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060484 lung-associated mesenchyme development IEP
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0060675 ureteric bud morphogenesis IEP
 biological_processGO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation IEA
 biological_processGO:0061037 negative regulation of cartilage development NAS
 biological_processGO:0061053 somite development IEA
 biological_processGO:0061101 neuroendocrine cell differentiation IMP
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071300 cellular response to retinoic acid ISS
 biological_processGO:0072177 mesonephric duct development IEP
 biological_processGO:0072201 negative regulation of mesenchymal cell proliferation IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030295 protein kinase activator activity IMP
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Ca2+ pathway
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000155760 FZD7 / O75084 / frizzled class receptor 7  / complex / reaction
 ENSG00000157240 FZD1 / Q9UP38 / frizzled class receptor 1  / complex / reaction






 

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