ENSG00000155760


Homo sapiens

Features
Gene ID: ENSG00000155760
  
Biological name :FZD7
  
Synonyms : frizzled class receptor 7 / FZD7 / O75084
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.1
Gene start: 202034587
Gene end: 202038445
  
Corresponding Affymetrix probe sets: 203705_s_at (Human Genome U133 Plus 2.0 Array)   203706_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000286201
NCBI entrez gene - 8324     See in Manteia.
OMIM - 603410
RefSeq - NM_003507
RefSeq Peptide - NP_003498
swissprot - O75084
Ensembl - ENSG00000155760
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd7aENSDARG00000060004Danio rerio
 fzd7bENSDARG00000027589Danio rerio
 FZD7ENSGALG00000034973Gallus gallus
 Fzd7ENSMUSG00000041075Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724078
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034078
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728347
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325147
FZD10 / Q9ULW2 / frizzled class receptor 10ENSG0000011143244
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876342
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480441
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429041
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493040
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860225
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648316
FRZB / Q92765 / frizzled related proteinENSG0000016299815
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433215
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005713
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026552  Frizzled-7
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035567 non-canonical Wnt signaling pathway IEA
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IMP
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0042666 negative regulation of ectodermal cell fate specification IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0046330 positive regulation of JNK cascade IC
 biological_processGO:0048103 somatic stem cell division IEA
 biological_processGO:0060054 positive regulation of epithelial cell proliferation involved in wound healing IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0060231 mesenchymal to epithelial transition IMP
 biological_processGO:0071300 cellular response to retinoic acid ISS
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IGI
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0055038 recycling endosome membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
PCP/CE pathway
Asymmetric localization of PCP proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000125084 WNT1 / P04628 / Wnt family member 1  / reaction / complex
 ENSG00000085741 WNT11 / O96014 / Wnt family member 11  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr