ENSG00000111432


Homo sapiens

Features
Gene ID: ENSG00000111432
  
Biological name :FZD10
  
Synonyms : frizzled class receptor 10 / FZD10 / Q9ULW2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.33
Gene start: 130162459
Gene end: 130165740
  
Corresponding Affymetrix probe sets: 219764_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229030
Ensembl peptide - ENSP00000438460
NCBI entrez gene - 11211     See in Manteia.
OMIM - 606147
RefSeq - NM_007197
RefSeq Peptide - NP_009128
swissprot - Q9ULW2
swissprot - F5H450
Ensembl - ENSG00000111432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd10ENSDARG00000068213Danio rerio
 ENSGALG00000002652Gallus gallus
 FZD10ENSGALG00000042003Gallus gallus
 Fzd10ENSMUSG00000081683Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD9 / O00144 / frizzled class receptor 9ENSG0000018876364
FZD4 / Q9ULV1 / frizzled class receptor 4ENSG0000017480449
FZD1 / Q9UP38 / frizzled class receptor 1ENSG0000015724045
FZD2 / Q14332 / frizzled class receptor 2ENSG0000018034044
FZD8 / Q9H461 / frizzled class receptor 8ENSG0000017728344
FZD7 / O75084 / frizzled class receptor 7ENSG0000015576044
FZD5 / Q13467 / frizzled class receptor 5ENSG0000016325143
FZD3 / Q9NPG1 / frizzled class receptor 3ENSG0000010429034
FZD6 / O60353 / frizzled class receptor 6ENSG0000016493033
SMO / Q99835 / smoothened, frizzled class receptorENSG0000012860222
SFRP4 / Q6FHJ7 / secreted frizzled related protein 4ENSG0000010648314
SFRP1 / Q8N474 / secreted frizzled related protein 1ENSG0000010433213
FRZB / Q92765 / frizzled related proteinENSG0000016299813
SFRP5 / Q5T4F7 / secreted frizzled related protein 5ENSG0000012005713
SFRP2 / Q96HF1 / secreted frizzled related protein 2ENSG0000014542312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026549  Frizzled-10
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0034260 negative regulation of GTPase activity IMP
 biological_processGO:0038031 non-canonical Wnt signaling pathway via JNK cascade IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0071300 cellular response to retinoic acid ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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