ENSG00000105989


Homo sapiens

Features
Gene ID: ENSG00000105989
  
Biological name :WNT2
  
Synonyms : P09544 / WNT2 / Wnt family member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.2
Gene start: 117276631
Gene end: 117323289
  
Corresponding Affymetrix probe sets: 205648_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389643
Ensembl peptide - ENSP00000419466
Ensembl peptide - ENSP00000265441
NCBI entrez gene - 7472     See in Manteia.
OMIM - 147870
RefSeq - NM_003391
RefSeq Peptide - NP_003382
swissprot - C9JUI2
swissprot - F8WDR1
swissprot - P09544
Ensembl - ENSG00000105989
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wnt2ENSDARG00000041117Danio rerio
 WNT2ENSGALG00000030173Gallus gallus
 Wnt2ENSMUSG00000010797Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WNT2B / Q93097 / Wnt family member 2BENSG0000013424568
WNT5A / P41221 / Wnt family member 5AENSG0000011425146
WNT5B / Q9H1J7 / Wnt family member 5BENSG0000011118646
WNT4 / P56705 / Wnt family member 4ENSG0000016255244
WNT7A / O00755 / Wnt family member 7AENSG0000015476443
WNT7B / P56706 / Wnt family member 7BENSG0000018806443
WNT3 / P56703 / Wnt family member 3ENSG0000010837943
WNT3A / P56704 / Wnt family member 3AENSG0000015434241
WNT1 / P04628 / Wnt family member 1ENSG0000012508440
WNT16 / Q9UBV4 / Wnt family member 16ENSG0000000274540
WNT6 / Q9Y6F9 / Wnt family member 6ENSG0000011559637
WNT11 / O96014 / Wnt family member 11ENSG0000008574134


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR009140  Wnt-2 protein
 IPR018161  Wnt protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002088 lens development in camera-type eye ISS
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0022008 neurogenesis TAS
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030324 lung development IEA
 biological_processGO:0033278 cell proliferation in midbrain IDA
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060492 lung induction IEA
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061072 iris morphogenesis ISS
 biological_processGO:0061180 mammary gland epithelium development IEP
 biological_processGO:0071300 cellular response to retinoic acid ISS
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IDA
 biological_processGO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:1990909 Wnt signalosome IC
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048018 receptor ligand activity IDA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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