ENSMUSG00000079019


Mus musculus

Features
Gene ID: ENSMUSG00000079019
  
Biological name :Insl3
  
Synonyms : Insl3
  
Possible biological names infered from orthology : insulin like 3 / P51460
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 71689214
Gene end: 71690575
  
Corresponding Affymetrix probe sets: 1423021_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034261
NCBI entrez gene - 16336     See in Manteia.
MGI - MGI:108427
RefSeq - NM_013564
RefSeq Peptide - NP_038592
swissprot - Q5RL10
Ensembl - ENSMUSG00000079019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSL3ENSG00000248099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR022352  Insulin family
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003557 absent vas deferens "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

 MP:0004727 absent epididymis "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0005149 abnormal gubernaculum morphology "dysmorphology of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55881]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Insl3tm1Par/Insl3+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053368 Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*  / complex / reaction
 ENSMUSG00000079019 Insl3 / P51460* / insulin like 3*  / complex






 

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