ENSDARG00000055100


Danio rerio

Features
Gene ID: ENSDARG00000055100
  
Biological name :cxcl12b
  
Synonyms : chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) / cxcl12b
  
Possible biological names infered from orthology : CXCL12 / C-X-C motif chemokine ligand 12 / P40224 / P48061 / Stromal cell-derived factor 1
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 26929554
Gene end: 26945493
  
Corresponding Affymetrix probe sets: Dr.61.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000071878
NCBI entrez gene - 799354     See in Manteia.
RefSeq - NM_001320414
RefSeq Peptide - NP_001307343
RefSeq Peptide - NP_932334
swissprot - Q6V9B5
ZFIN ID - ZDB-GENE-030721-1
Ensembl - ENSDARG00000055100
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCL12ENSGALG00000041346Gallus gallus
 CXCL12ENSG00000107562Homo sapiens
 Cxcl12ENSMUSG00000061353Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cxcl12a / chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*ENSDARG0000003711674


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR033899  CXC Chemokine domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0021730 trigeminal sensory nucleus development IGI
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031290 retinal ganglion cell axon guidance IGI
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IGI
 biological_processGO:0051453 regulation of intracellular pH IGI
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0097535 lymphoid lineage cell migration into thymus IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000112 gut gut bifurcated , abnormal
gut morphology , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver duplicated , abnormal
Show

 ZFA:0000140 pancreas pancreas morphology , abnormal
pancreas decreased size , abnormal
pancreas pancreatic B cell dispersed , abnormal
pancreas duplicated , abnormal
Show

 ZFA:0000155 somite somite cellular quality , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion axon position , abnormal
Show

 ZFA:0000405 cranial nerve III cranial nerve III mislocalised , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel angiogenic sprout decreased amount , abnormal
Show

 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta malformed , abnormal
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 ZFA:0001078 thymus thymus has fewer parts of type lymphocyte , abnormal
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 ZFA:0001114 head head neutrophil aggregated , abnormal
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 ZFA:0001338 intestine intestine duplicated , abnormal
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 ZFA:0005002 basilar artery basilar artery unlumenized , abnormal
basilar artery agenesis , abnormal
basilar artery absent , abnormal
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 ZFA:0005020 central artery central artery physical object quality , abnormal
central artery malformed , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta lymphocyte decreased amount , abnormal
Show

 ZFA:0005768 trigeminal sensory neuron trigeminal sensory neuron mislocalised , abnormal
trigeminal sensory neuron cell migration process quality , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell circular , abnormal
endodermal cell filopodium orientation whole organism dorsal-ventral axis, abnormal
endodermal cell filopodium decreased amount , abnormal
endodermal cell mislocalised anteriorly , abnormal
endodermal cell displaced to margin , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell establishment of cell polarity decreased occurrence , abnormal
primordial germ cell regulation of intracellular pH process quality , abnormal
Show

 ZFA:0009327 neutrophil neutrophil mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000062478 ackr3a / atypical chemokine receptor 3a / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*  / complex / reaction
 ENSDARG00000004246 slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*  / reaction / complex
 ENSDARG00000041959 cxcr4b / chemokine (C-X-C motif), receptor 4b / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*  / reaction / complex
 ENSDARG00000058179 ackr3b / atypical chemokine receptor 3b / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*  / reaction / complex






 

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