ENSMUSG00000044534


Mus musculus

Features
Gene ID: ENSMUSG00000044534
  
Biological name :Ackr2
  
Synonyms : Ackr2 / atypical chemokine receptor 2 / O08707
  
Possible biological names infered from orthology : O00590
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 121898355
Gene end: 121911074
  
Corresponding Affymetrix probe sets: 10590427 (MoGene1.0st)   1422111_at (Mouse Genome 430 2.0 Array)   1422112_at (Mouse Genome 430 2.0 Array)   1437937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150219
Ensembl peptide - ENSMUSP00000151092
Ensembl peptide - ENSMUSP00000050119
Ensembl peptide - ENSMUSP00000148966
NCBI entrez gene - 59289     See in Manteia.
MGI - MGI:1891697
RefSeq - XM_006512203
RefSeq - XM_006512204
RefSeq - NM_001276719
RefSeq - NM_021609
RefSeq Peptide - NP_001263648
RefSeq Peptide - NP_067622
swissprot - O08707
swissprot - A0A1L1SV85
swissprot - A0A1L1ST82
Ensembl - ENSMUSG00000044534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ACKR2ENSGALG00000005305Gallus gallus
 ACKR2ENSG00000144648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910334
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789833
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226233
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922732
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089930
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405230
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233630
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023230
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580430
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953029
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544829
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848029
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538228
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788028
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403927
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050927
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794427
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935526
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618026
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR033037  Atypical chemokine receptor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA
 molecular_functionGO:0019957 C-C chemokine binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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