ENSMUSG00000071005


Mus musculus

Features
Gene ID: ENSMUSG00000071005
  
Biological name :Ccl19
  
Synonyms : Ccl19 / C-C motif chemokine 19 / O70460
  
Possible biological names infered from orthology : C-C motif chemokine ligand 19 / Q99731
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 42754525
Gene end: 42756577
  
Corresponding Affymetrix probe sets: 10504132 (MoGene1.0st)   10504159 (MoGene1.0st)   10504188 (MoGene1.0st)   10512322 (MoGene1.0st)   10512372 (MoGene1.0st)   1449277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144891
Ensembl peptide - ENSMUSP00000100022
NCBI entrez gene - 24047     See in Manteia.
MGI - MGI:1346316
RefSeq - NM_011888
RefSeq Peptide - NP_036018
swissprot - A0A0N4SUZ8
swissprot - O70460
swissprot - Q548P0
Ensembl - ENSMUSG00000071005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl19a.2ENSDARG00000035632Danio rerio
 ccl19bENSDARG00000039351Danio rerio
 CCL19ENSGALG00000028256Gallus gallus
 CCL19ENSG00000172724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm2564 / CCL19* / Q99731* / C-C motif chemokine ligand 19*ENSMUSG0000009193899


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR034133  Chemokine CC, DCCL motif-cointaining domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001768 establishment of T cell polarity ISO
 biological_processGO:0001771 immunological synapse formation IDA
 biological_processGO:0002407 dendritic cell chemotaxis IDA
 biological_processGO:0002408 myeloid dendritic cell chemotaxis ISS
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process IDA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0034695 response to prostaglandin E ISO
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IDA
 biological_processGO:0045807 positive regulation of endocytosis IDA
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IDA
 biological_processGO:0048469 cell maturation IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060491 regulation of cell projection assembly IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0071731 response to nitric oxide ISO
 biological_processGO:0072610 interleukin-12 secretion IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISO
 biological_processGO:0097029 mature conventional dendritic cell differentiation IDA
 biological_processGO:0098586 cellular response to virus ISO
 biological_processGO:2000147 positive regulation of cell motility ISO
 biological_processGO:2000549 positive regulation of dendritic cell dendrite assembly IDA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0031732 CCR7 chemokine receptor binding IPI
 molecular_functionGO:0031735 CCR10 chemokine receptor binding ISO
 molecular_functionGO:0042379 chemokine receptor binding ISS
 molecular_functionGO:0048020 CCR chemokine receptor binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm1Brn/Brca1tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm1Brn/Brca1tm1Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037944 Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*  / reaction / complex
 ENSMUSG00000079355 Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*  / reaction / complex
 ENSMUSG00000043953 Ccrl2 / O35457 / C-C chemokine receptor-like 2 / O00421* / C-C motif chemokine receptor like 2*  / complex / reaction






 

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