ENSG00000172724


Homo sapiens

Features
Gene ID: ENSG00000172724
  
Biological name :CCL19
  
Synonyms : CCL19 / C-C motif chemokine ligand 19 / Q99731
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p13.3
Gene start: 34689567
Gene end: 34691277
  
Corresponding Affymetrix probe sets: 210072_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308815
Ensembl peptide - ENSP00000368077
NCBI entrez gene - 6363     See in Manteia.
OMIM - 602227
RefSeq - NM_006274
RefSeq Peptide - NP_006265
swissprot - Q5VZ75
swissprot - Q6IBD6
swissprot - Q99731
Ensembl - ENSG00000172724
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl19a.2ENSDARG00000035632Danio rerio
 ccl19bENSDARG00000039351Danio rerio
 CCL19ENSGALG00000028256Gallus gallus
 Ccl19ENSMUSG00000071005Mus musculus
 Gm2564ENSMUSG00000091938Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR034133  Chemokine CC, DCCL motif-cointaining domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001768 establishment of T cell polarity IDA
 biological_processGO:0001771 immunological synapse formation ISS
 biological_processGO:0002407 dendritic cell chemotaxis IDA
 biological_processGO:0002408 myeloid dendritic cell chemotaxis IDA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
 biological_processGO:0006874 cellular calcium ion homeostasis TAS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007154 cell communication TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007257 activation of JUN kinase activity ISS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031295 T cell costimulation ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0034695 response to prostaglandin E IDA
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation ISS
 biological_processGO:0045807 positive regulation of endocytosis ISS
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis ISS
 biological_processGO:0048469 cell maturation ISS
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISS
 biological_processGO:0050921 positive regulation of chemotaxis ISS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060491 regulation of cell projection assembly ISS
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0071731 response to nitric oxide IDA
 biological_processGO:0072610 interleukin-12 secretion ISS
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:0097029 mature conventional dendritic cell differentiation ISS
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:2000147 positive regulation of cell motility IDA
 biological_processGO:2000549 positive regulation of dendritic cell dendrite assembly ISS
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0031732 CCR7 chemokine receptor binding ISS
 molecular_functionGO:0031735 CCR10 chemokine receptor binding IDA
 molecular_functionGO:0042379 chemokine receptor binding IDA
 molecular_functionGO:0048020 CCR chemokine receptor binding IPI


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126353 CCR7 / P32248 / C-C motif chemokine receptor 7  / complex / reaction
 ENSG00000129048 ACKR4 / Q9NPB9 / atypical chemokine receptor 4  / reaction / complex
 ENSG00000121797 CCRL2 / O00421 / C-C motif chemokine receptor like 2  / complex / reaction






 

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