ENSG00000112486


Homo sapiens

Features
Gene ID: ENSG00000112486
  
Biological name :CCR6
  
Synonyms : C-C motif chemokine receptor 6 / CCR6 / P51684
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q27
Gene start: 167111807
Gene end: 167139696
  
Corresponding Affymetrix probe sets: 206983_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000493637
Ensembl peptide - ENSP00000495402
Ensembl peptide - ENSP00000339393
Ensembl peptide - ENSP00000343952
Ensembl peptide - ENSP00000383715
NCBI entrez gene - 1235     See in Manteia.
OMIM - 601835
RefSeq - NM_004367
RefSeq - NM_031409
RefSeq Peptide - NP_004358
RefSeq Peptide - NP_113597
swissprot - P51684
Ensembl - ENSG00000112486
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr6aENSDARG00000087474Danio rerio
 ccr6bENSDARG00000038968Danio rerio
 CCR6ENSGALG00000011418Gallus gallus
 Ccr6ENSMUSG00000040899Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635339
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346437
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358534
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087134
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381333
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832932
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681032
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904832
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221532
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362531
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445130
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382330
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079129
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464829
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196629
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993429
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180729
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068328
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR004067  CC chemokine receptor 6
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0002523 leukocyte migration involved in inflammatory response ISS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0048290 isotype switching to IgA isotypes ISS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060474 positive regulation of flagellated sperm motility involved in capacitation IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0072676 lymphocyte migration ISS
 biological_processGO:0072678 T cell migration ISS
 biological_processGO:0072679 thymocyte migration ISS
 biological_processGO:1904155 DN2 thymocyte differentiation ISS
 biological_processGO:1904156 DN3 thymocyte differentiation ISS
 biological_processGO:2000404 regulation of T cell migration ISS
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036126 sperm flagellum IDA
 cellular_componentGO:0097225 sperm midpiece IDA
 cellular_componentGO:0097228 sperm principal piece IDA
 cellular_componentGO:0097524 sperm plasma membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IMP
 molecular_functionGO:0019957 C-C chemokine binding IMP


Pathways (from Reactome)
Pathway description
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000083 Renal failure 
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 HP:0000217 Xerostomia "Dryness of the mouth due to salivary gland dysfunction." [HPO:curators]
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 HP:0000670 Carious teeth 
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 HP:0001053 Hypopigmented skin patches 
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 HP:0001324 Muscle weakness "Reduced strength of muscles." [HPO:curators]
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 HP:0001369 Arthritis 
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 HP:0001371 Contractures 
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 HP:0001635 Congestive heart failure "The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction." [HPO:curators]
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 HP:0002015 Dysphagia "Difficulty in swallowing." [HPO:curators]
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 HP:0002017 Nausea and vomiting 
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 HP:0002020 Gastroesophageal reflux 
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 HP:0002024 Malabsorption 
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 HP:0002092 Pulmonary hypertension 
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 HP:0002094 Dyspnea 
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 HP:0002113 Pulmonary infiltrates 
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 HP:0002206 Pulmonary fibrosis 
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 HP:0002797 Osteolysis 
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 HP:0002829 Arthralgia 
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 HP:0002960 Autoimmune disease 
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 HP:0008366 Contractures involving the joints of the feet 
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 HP:0009473 Joint contractures involving the joints of the hand 
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 HP:0030016 Dyspareunia "Recurrent or persistent genital pain associated with sexual intercourse." []
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 HP:0030142 Abnormal bowel sounds "An anomaly of the amount or nature of abdominal sounds. Abdominal sounds (bowel sounds) are made by the movement of the intestines as they promote passage of abdominal contents by peristalsis." []
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 HP:0100520 Oliguria "Low output of urine, clinically classified as an output below 300-500ml/day." [HPO:sdoelken]
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 HP:0100579 Mucosal telangiectasiae "`Telangiectasia` (HP:0001009) of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs." [HPO:sdoelken]
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 HP:0100585 Teleangiectasia of the skin 
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 HP:0100735 Hypertensive crisis 
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 HP:0100958 Narrow foramen obturatorium 
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 HP:0200042 skin ulcer "A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat." [HPO:SKOEHLER]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164825 DEFB1 / P60022 / defensin beta 1  / reaction / complex
 ENSG00000177243 P81534 / DEFB103B / defensin beta 103B  / reaction / complex
 ENSG00000177257 DEFB4B / O15263 / defensin beta 4B  / reaction / complex
 ENSG00000115009 CCL20 / P78556 / C-C motif chemokine ligand 20  / complex / reaction






 

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