ENSG00000143184


Homo sapiens

Features
Gene ID: ENSG00000143184
  
Biological name :XCL1
  
Synonyms : P47992 / XCL1 / X-C motif chemokine ligand 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.2
Gene start: 168576473
Gene end: 168582077
  
Corresponding Affymetrix probe sets: 206365_at (Human Genome U133 Plus 2.0 Array)   206366_x_at (Human Genome U133 Plus 2.0 Array)   214567_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356792
NCBI entrez gene - 6375     See in Manteia.
OMIM - 600250
RefSeq - NM_002995
RefSeq - XM_011509865
RefSeq Peptide - NP_002986
swissprot - P47992
Ensembl - ENSG00000143184
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 XCL1ENSGALG00000015235Gallus gallus
 Xcl1ENSMUSG00000026573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
XCL2 / Q9UBD3 / X-C motif chemokine ligand 2ENSG0000014318598


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR008105  C chemokine
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis ISS
 biological_processGO:0002725 negative regulation of T cell cytokine production IDA
 biological_processGO:0002726 positive regulation of T cell cytokine production ISS
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IC
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IC
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IDA
 biological_processGO:0030593 neutrophil chemotaxis TAS
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032703 negative regulation of interleukin-2 production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0035782 mature natural killer cell chemotaxis IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071353 cellular response to interleukin-4 ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISS
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IDA
 biological_processGO:0071663 positive regulation of granzyme B production IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISS
 biological_processGO:2000412 positive regulation of thymocyte migration ISS
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IDA
 biological_processGO:2000513 positive regulation of granzyme A production IDA
 biological_processGO:2000518 negative regulation of T-helper 1 cell activation IDA
 biological_processGO:2000538 positive regulation of B cell chemotaxis ISS
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production ISS
 biological_processGO:2000556 positive regulation of T-helper 1 cell cytokine production ISS
 biological_processGO:2000558 positive regulation of immunoglobulin production in mucosal tissue ISS
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation ISS
 biological_processGO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0042379 chemokine receptor binding NAS
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173578 XCR1 / P46094 / X-C motif chemokine receptor 1  / complex / reaction






 

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