ENSMUSG00000026573


Mus musculus

Features
Gene ID: ENSMUSG00000026573
  
Biological name :Xcl1
  
Synonyms : chemokine (C motif) ligand 1 / P47993 / Xcl1
  
Possible biological names infered from orthology : P47992 / Q9UBD3 / XCL2 / X-C motif chemokine ligand 1 / X-C motif chemokine ligand 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.2
Gene start: 164931644
Gene end: 164935527
  
Corresponding Affymetrix probe sets: 10359697 (MoGene1.0st)   1419412_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027860
NCBI entrez gene - 16963     See in Manteia.
MGI - MGI:104593
RefSeq - NM_008510
RefSeq Peptide - NP_032536
swissprot - P47993
swissprot - Q542T1
Ensembl - ENSMUSG00000026573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 XCL1ENSGALG00000015235Gallus gallus
 XCL1ENSG00000143184Homo sapiens
 XCL2ENSG00000143185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR008105  C chemokine
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity ISS
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IDA
 biological_processGO:0002725 negative regulation of T cell cytokine production ISO
 biological_processGO:0002726 positive regulation of T cell cytokine production IDA
 biological_processGO:0002839 positive regulation of immune response to tumor cell NAS
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling ISO
 biological_processGO:0009615 response to virus ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production ISS
 biological_processGO:0032703 negative regulation of interleukin-2 production ISS
 biological_processGO:0032733 positive regulation of interleukin-10 production ISS
 biological_processGO:0035782 mature natural killer cell chemotaxis IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045089 positive regulation of innate immune response IC
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol ISS
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production ISS
 biological_processGO:0071663 positive regulation of granzyme B production ISO
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:2000412 positive regulation of thymocyte migration IDA
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis ISS
 biological_processGO:2000513 positive regulation of granzyme A production ISO
 biological_processGO:2000518 negative regulation of T-helper 1 cell activation ISO
 biological_processGO:2000538 positive regulation of B cell chemotaxis IDA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IDA
 biological_processGO:2000556 positive regulation of T-helper 1 cell cytokine production IDA
 biological_processGO:2000558 positive regulation of immunoglobulin production in mucosal tissue IDA
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
 biological_processGO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0042379 chemokine receptor binding NAS
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ate1tm1Avar/Ate1+
Genetic Background: involves: 129S1/Sv

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ate1tm1Avar/Ate1+
Genetic Background: involves: 129S1/Sv

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Ate1tm1Avar/Ate1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Xcl1tm1Rakr/Xcl1tm1Rakr
Genetic Background: B6.129-Xcl1tm1Rakr

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ate1tm1Avar/Ate1+
Genetic Background: involves: 129S1/Sv

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cttntm1.2Dvst/Cttn+
Genetic Background: B6.Cg-Cttntm1.2Dvst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060509 Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*  / reaction / complex






 

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