ENSMUSG00000028860


Mus musculus

Features
Gene ID: ENSMUSG00000028860
  
Biological name :Sytl1
  
Synonyms : synaptotagmin like 1 / Sytl1
  
Possible biological names infered from orthology : Q8IYJ3
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 133253090
Gene end: 133263113
  
Corresponding Affymetrix probe sets: 10517009 (MoGene1.0st)   1450240_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030674
Ensembl peptide - ENSMUSP00000101528
NCBI entrez gene - 269589     See in Manteia.
MGI - MGI:1933365
RefSeq - NM_031393
RefSeq - XM_011250265
RefSeq Peptide - NP_113570
swissprot - A2AE95
swissprot - A2AE94
Ensembl - ENSMUSG00000028860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sytl1ENSDARG00000070094Danio rerio
 SYTL1ENSG00000142765Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sytl2 / Q99N50 / Synaptotagmin-like protein 2 / Q9HCH5* / synaptotagmin like 2*ENSMUSG0000003061640
Sytl4 / Q9R0Q1 / synaptotagmin-like 4 / Q96C24*ENSMUSG0000003125532
Sytl5 / Q80T23 / synaptotagmin-like 5 / Q8TDW5*ENSMUSG0000005445332
Sytl3 / Q99N48 / Synaptotagmin-like protein 3 / Q4VX76* / synaptotagmin like 3*ENSMUSG0000004183125
Rph3a / P47708 / Rabphilin-3A / Q9Y2J0*ENSMUSG0000002960820
Doc2a / Q7TNF0 / Double C2-like domain-containing protein alpha / Q14183* / double C2 domain alpha*ENSMUSG0000005230117
Doc2b / P70169 / Double C2-like domain-containing protein beta / double C2 domain beta*ENSMUSG0000002084816
Doc2gENSMUSG0000002487115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR010911  Rab-binding domain
 IPR028378  Synaptotagmin-like protein 1
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gdf5Bp-5J/Gdf5+
Genetic Background: C57BL/6J-Gdf5Bp-5J/GrsrJ

Allelic Composition: Sytl1tm1Tiz/Sytl1tm1Tiz,Sytl4tm1Tiz/Sytl4tm1Tiz
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003596 epididymal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004614 caudal vertebral transformation "homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sytl1tm1Tiz/Sytl1tm1Tiz,Sytl4tm1Tiz/Sytl4tm1Tiz
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034412 P58802 / Tbc1d10a / TBC1 domain family member 10A / Q9BXI6* / AC004997.1*  / reaction / complex






 

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