ENSMUSG00000031255


Mus musculus

Features
Gene ID: ENSMUSG00000031255
  
Biological name :Sytl4
  
Synonyms : Q9R0Q1 / synaptotagmin-like 4 / Sytl4
  
Possible biological names infered from orthology : Q96C24
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: E3
Gene start: 133936385
Gene end: 133981812
  
Corresponding Affymetrix probe sets: 10606619 (MoGene1.0st)   1417336_a_at (Mouse Genome 430 2.0 Array)   1425998_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033608
Ensembl peptide - ENSMUSP00000108919
Ensembl peptide - ENSMUSP00000108922
Ensembl peptide - ENSMUSP00000134030
NCBI entrez gene - 27359     See in Manteia.
MGI - MGI:1351606
RefSeq - XM_006528551
RefSeq - NM_001290717
RefSeq - NM_001290718
RefSeq - NM_001290719
RefSeq - NM_013757
RefSeq Peptide - NP_001277646
RefSeq Peptide - NP_001277647
RefSeq Peptide - NP_001277648
RefSeq Peptide - NP_038785
swissprot - Q549X6
swissprot - Q9R0Q1
swissprot - G3UYC6
Ensembl - ENSMUSG00000031255
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sytl4ENSDARG00000102433Danio rerio
 SYTL4ENSGALG00000006786Gallus gallus
 SYTL4ENSG00000102362Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sytl5 / Q80T23 / synaptotagmin-like 5 / Q8TDW5*ENSMUSG0000005445342
Sytl2 / Q99N50 / Synaptotagmin-like protein 2 / Q9HCH5* / synaptotagmin like 2*ENSMUSG0000003061632
Sytl3 / Q99N48 / Synaptotagmin-like protein 3 / Q4VX76* / synaptotagmin like 3*ENSMUSG0000004183129
Sytl1 / synaptotagmin like 1 / Q8IYJ3*ENSMUSG0000002886027
Rph3a / P47708 / Rabphilin-3A / Q9Y2J0*ENSMUSG0000002960822
Doc2b / P70169 / Double C2-like domain-containing protein beta / double C2 domain beta*ENSMUSG0000002084817
Doc2a / Q7TNF0 / Double C2-like domain-containing protein alpha / Q14183* / double C2 domain alpha*ENSMUSG0000005230117
Doc2gENSMUSG0000002487113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR028694  Synaptotagmin-like protein 4
 IPR035892  C2 domain superfamily
 IPR037303  Synaptotagmin-like protein 4/5, C2A domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0045921 positive regulation of exocytosis ISO
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050714 positive regulation of protein secretion ISO
 biological_processGO:0071985 multivesicular body sorting pathway ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005768 endosome ISO
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0042043 neurexin family protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001747 hypersecretion of adrenocorticotropin 
Show

Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sytl1tm1Tiz/Sytl1tm1Tiz,Sytl4tm1Tiz/Sytl4tm1Tiz
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sytl1tm1Tiz/Sytl1tm1Tiz,Sytl4tm1Tiz/Sytl4tm1Tiz
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008327 abnormal corticotroph morphology "any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)" [CL:0000467, MESH:A06.407.747.608.500]
Show

Allelic Composition: Gli2tm1Blnw/Gli2tm1Blnw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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