ENSG00000102362


Homo sapiens

Features
Gene ID: ENSG00000102362
  
Biological name :SYTL4
  
Synonyms : Q96C24 / synaptotagmin like 4 / SYTL4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.1
Gene start: 100674491
Gene end: 100732123
  
Corresponding Affymetrix probe sets: 1563513_at (Human Genome U133 Plus 2.0 Array)   227703_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362080
Ensembl peptide - ENSP00000263033
Ensembl peptide - ENSP00000276141
Ensembl peptide - ENSP00000362072
NCBI entrez gene - 94121     See in Manteia.
OMIM - 300723
RefSeq - XM_017029971
RefSeq - NM_001129896
RefSeq - NM_001174068
RefSeq - NM_080737
RefSeq - XM_017029966
RefSeq - XM_017029967
RefSeq - XM_017029968
RefSeq - XM_017029969
RefSeq - XM_017029970
RefSeq - XM_005262229
RefSeq - XM_011531068
RefSeq Peptide - NP_001123368
RefSeq Peptide - NP_001167539
RefSeq Peptide - NP_542775
swissprot - Q96C24
swissprot - A0A024RCF8
Ensembl - ENSG00000102362
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sytl4ENSDARG00000102433Danio rerio
 SYTL4ENSGALG00000006786Gallus gallus
 Sytl4ENSMUSG00000031255Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYTL5 / Q8TDW5 / synaptotagmin like 5ENSG0000014704143
SYTL2 / Q9HCH5 / synaptotagmin like 2ENSG0000013750132
SYTL3 / Q4VX76 / synaptotagmin like 3ENSG0000016467430
SYTL1 / Q8IYJ3 / synaptotagmin like 1ENSG0000014276527
RPH3A / Q9Y2J0 / rabphilin 3AENSG0000008916923
DOC2B / double C2 domain betaENSG0000027263617
DOC2A / Q14183 / double C2 domain alphaENSG0000014992716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR028694  Synaptotagmin-like protein 4
 IPR035892  C2 domain superfamily
 IPR037303  Synaptotagmin-like protein 4/5, C2A domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050714 positive regulation of protein secretion IMP
 biological_processGO:0071985 multivesicular body sorting pathway IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031092 platelet alpha granule membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding ISS
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0042043 neurexin family protein binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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