ENSG00000149927


Homo sapiens

Features
Gene ID: ENSG00000149927
  
Biological name :DOC2A
  
Synonyms : DOC2A / double C2 domain alpha / Q14183
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p11.2
Gene start: 30005509
Gene end: 30023270
  
Corresponding Affymetrix probe sets: 205744_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482870
Ensembl peptide - ENSP00000458670
Ensembl peptide - ENSP00000460622
Ensembl peptide - ENSP00000340017
Ensembl peptide - ENSP00000454827
Ensembl peptide - ENSP00000454857
Ensembl peptide - ENSP00000455196
Ensembl peptide - ENSP00000455624
Ensembl peptide - ENSP00000456704
Ensembl peptide - ENSP00000457184
Ensembl peptide - ENSP00000457454
NCBI entrez gene - 8448     See in Manteia.
OMIM - 604567
RefSeq - XM_017023778
RefSeq - NM_001282062
RefSeq - NM_001282063
RefSeq - NM_001282068
RefSeq - NM_003586
RefSeq - XM_011545975
RefSeq - XM_017023776
RefSeq - XM_017023777
RefSeq Peptide - NP_001268992
RefSeq Peptide - NP_001268991
RefSeq Peptide - NP_001268997
RefSeq Peptide - NP_003577
swissprot - H3BU41
swissprot - I3L194
swissprot - I3L3P9
swissprot - H3BTI1
swissprot - H3BNF7
swissprot - H3BSH4
swissprot - Q14183
Ensembl - ENSG00000149927
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-93n13.3ENSDARG00000078736Danio rerio
 Doc2aENSMUSG00000052301Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOC2B / double C2 domain betaENSG0000027263663
RPH3A / Q9Y2J0 / rabphilin 3AENSG0000008916957
SYTL4 / Q96C24 / synaptotagmin like 4ENSG0000010236227
SYTL5 / Q8TDW5 / synaptotagmin like 5ENSG0000014704126
SYTL2 / Q9HCH5 / synaptotagmin like 2ENSG0000013750125
SYTL1 / Q8IYJ3 / synaptotagmin like 1ENSG0000014276523
SYTL3 / Q4VX76 / synaptotagmin like 3ENSG0000016467420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR014638  Double C2 protein, alpha/beta/gamma
 IPR030535  Double C2-like domain-containing protein alpha
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IBA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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