ENSMUSG00000030616


Mus musculus

Features
Gene ID: ENSMUSG00000030616
  
Biological name :Sytl2
  
Synonyms : Q99N50 / Synaptotagmin-like protein 2 / Sytl2
  
Possible biological names infered from orthology : Q9HCH5 / synaptotagmin like 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 90302252
Gene end: 90410719
  
Corresponding Affymetrix probe sets: 10554863 (MoGene1.0st)   1421594_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146353
Ensembl peptide - ENSMUSP00000139865
Ensembl peptide - ENSMUSP00000147191
Ensembl peptide - ENSMUSP00000102828
Ensembl peptide - ENSMUSP00000102829
Ensembl peptide - ENSMUSP00000139450
NCBI entrez gene - 83671     See in Manteia.
MGI - MGI:1933366
RefSeq - XM_006508359
RefSeq - NM_001289583
RefSeq - NM_001289584
RefSeq - NM_031394
RefSeq - XM_006508355
RefSeq - XM_006508356
RefSeq - XM_006508357
RefSeq - XM_006508358
RefSeq - NM_001040085
RefSeq Peptide - NP_113571
RefSeq Peptide - NP_001035174
RefSeq Peptide - NP_001276512
RefSeq Peptide - NP_001276513
swissprot - Q99N50
swissprot - A0A140LJF2
swissprot - A0A140LHC0
Ensembl - ENSMUSG00000030616
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sytl2aENSDARG00000061956Danio rerio
 sytl2bENSDARG00000075436Danio rerio
 ENSGALG00000008326Gallus gallus
 SYTL2ENSG00000137501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sytl1 / synaptotagmin like 1 / Q8IYJ3*ENSMUSG0000002886024
Sytl5 / Q80T23 / synaptotagmin-like 5 / Q8TDW5*ENSMUSG0000005445323
Sytl4 / Q9R0Q1 / synaptotagmin-like 4 / Q96C24*ENSMUSG0000003125522
Sytl3 / Q99N48 / Synaptotagmin-like protein 3 / Q4VX76* / synaptotagmin like 3*ENSMUSG0000004183117
Rph3a / P47708 / Rabphilin-3A / Q9Y2J0*ENSMUSG0000002960813
Doc2a / Q7TNF0 / Double C2-like domain-containing protein alpha / Q14183* / double C2 domain alpha*ENSMUSG0000005230111
Doc2b / P70169 / Double C2-like domain-containing protein beta / double C2 domain beta*ENSMUSG0000002084811
Doc2gENSMUSG000000248719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR010911  Rab-binding domain
 IPR027006  Synaptotagmin-like protein 2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis ISO
 biological_processGO:0006904 vesicle docking involved in exocytosis ISO
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0010923 negative regulation of phosphatase activity ISS
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0072659 protein localization to plasma membrane IDA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0033162 melanosome membrane IEA
 cellular_componentGO:0042470 melanosome IDA
 cellular_componentGO:0070382 exocytic vesicle IBA
 molecular_functionGO:0001786 phosphatidylserine binding ISO
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019902 phosphatase binding ISS
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0042043 neurexin family protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0004137 abnormal gastric surface mucous cells "malformation of the mucus secreting epithelial cells that lline the luminal surface of the stomach, gastric pits and gastric glands" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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