ENSMUSG00000020848


Mus musculus

Features
Gene ID: ENSMUSG00000020848
  
Biological name :Doc2b
  
Synonyms : Doc2b / Double C2-like domain-containing protein beta / P70169
  
Possible biological names infered from orthology : double C2 domain beta
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75768966
Gene end: 75796049
  
Corresponding Affymetrix probe sets: 10388465 (MoGene1.0st)   1420666_at (Mouse Genome 430 2.0 Array)   1420667_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021209
NCBI entrez gene - 13447     See in Manteia.
MGI - MGI:1100497
RefSeq - NM_007873
RefSeq Peptide - NP_031899
swissprot - P70169
Ensembl - ENSMUSG00000020848
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 doc2bENSDARG00000088293Danio rerio
 ENSGALG00000004917Gallus gallus
 DOC2BENSG00000272636Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rph3a / P47708 / Rabphilin-3A / Q9Y2J0*ENSMUSG0000002960862
Doc2a / Q7TNF0 / Double C2-like domain-containing protein alpha / Q14183* / double C2 domain alpha*ENSMUSG0000005230162
Doc2gENSMUSG0000002487147
Sytl4 / Q9R0Q1 / synaptotagmin-like 4 / Q96C24*ENSMUSG0000003125527
Sytl5 / Q80T23 / synaptotagmin-like 5 / Q8TDW5*ENSMUSG0000005445326
Sytl2 / Q99N50 / Synaptotagmin-like protein 2 / Q9HCH5* / synaptotagmin like 2*ENSMUSG0000003061625
Sytl1 / synaptotagmin like 1 / Q8IYJ3*ENSMUSG0000002886023
Sytl3 / Q99N48 / Synaptotagmin-like protein 3 / Q4VX76* / synaptotagmin like 3*ENSMUSG0000004183120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR014638  Double C2 protein, alpha/beta/gamma
 IPR030534  Double C2-like domain-containing protein beta
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0031340 positive regulation of vesicle fusion ISS
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis ISS
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031201 SNARE complex ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070382 exocytic vesicle IBA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0019905 syntaxin binding IPI
 molecular_functionGO:0030276 clathrin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgi1tm1.1Jkc/Lgi1tm1.1Jkc,Tyrc-Brd/Tyrc-Brd
Genetic Background: B6.Cg-Tyrc-Brd Lgi1tm1.1Jkc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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