ENSMUSG00000018697


Mus musculus

Features
Gene ID: ENSMUSG00000018697
  
Biological name :Aatf
  
Synonyms : Aatf / apoptosis antagonizing transcription factor / Q9JKX4
  
Possible biological names infered from orthology : Q9NY61
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 84422855
Gene end: 84513522
  
Corresponding Affymetrix probe sets: 10389269 (MoGene1.0st)   1432394_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018841
NCBI entrez gene - 56321     See in Manteia.
MGI - MGI:1929608
RefSeq - XM_011249153
RefSeq - NM_019816
RefSeq - XM_006533789
RefSeq Peptide - NP_062790
swissprot - Q9JKX4
Ensembl - ENSMUSG00000018697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aatfENSDARG00000025467Danio rerio
 AATFENSGALG00000005420Gallus gallus
 AATFENSG00000275700Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012617  Apoptosis-antagonizing transcription factor, C-terminal
 IPR025160  AATF leucine zipper-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0032929 negative regulation of superoxide anion generation IEA
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0042254 ribosome biogenesis IMP
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043522 leucine zipper domain binding IEA
 molecular_functionGO:0048156 tau protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0012111 failure of morula compaction "inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable" [MGI:anna]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0012129 failure of blastocyst formation "inability to form a blastocyst from a solid ball of cells known as a morula" [MGI:anna]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000025151 Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*  / reaction / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex / reaction
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / reaction / complex






 

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