ENSMUSG00000025132


Mus musculus

Features
Gene ID: ENSMUSG00000025132
  
Biological name :Arhgdia
  
Synonyms : Arhgdia / Q99PT1 / Rho GDP-dissociation inhibitor 1
  
Possible biological names infered from orthology : P52565 / Rho GDP dissociation inhibitor alpha
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120578104
Gene end: 120581624
  
Corresponding Affymetrix probe sets: 10393836 (MoGene1.0st)   1451168_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063714
Ensembl peptide - ENSMUSP00000101803
NCBI entrez gene - 192662     See in Manteia.
MGI - MGI:2178103
RefSeq - XM_006532549
RefSeq - NM_133796
RefSeq Peptide - NP_598557
swissprot - Q99PT1
Ensembl - ENSMUSG00000025132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgdiaENSDARG00000043795Danio rerio
 ARHGDIAENSGALG00000008443Gallus gallus
 P52565ENSG00000141522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61599 / Arhgdib / Rho GDP-dissociation inhibitor 2 / P52566* / Rho GDP dissociation inhibitor beta*ENSMUSG0000003022065
Q62160 / Arhgdig / Rho GDP-dissociation inhibitor 3 / Q99819* / Rho GDP dissociation inhibitor gamma*ENSMUSG0000007343353


Protein motifs (from Interpro)
Interpro ID Name
 IPR000406  Rho protein GDP-dissociation inhibitor
 IPR014756  Immunoglobulin E-set
 IPR024792  Rho GDP-dissociation inhibitor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032880 regulation of protein localization IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071461 cellular response to redox state IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISO
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005094 Rho GDP-dissociation inhibitor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005504 fatty acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
Rho GTPase cycle
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004757 abnormal distal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008137 absent podocytes "absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Arhgdiatm1Ytk/Arhgdiatm1Ytk,Arhgdibtm1Miyo/Arhgdibtm1Miyo
Genetic Background: involves: 129S/SvEv

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011428 mesangial cell hypoplasia "decreased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex
 ENSMUSG00000036634 Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / complex / reaction
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / complex / reaction
 ENSMUSG00000020458 Rtn4 / Q99P72 / reticulon 4 / Q9NQC3*  / complex / reaction
 ENSMUSG00000049612 Omg / oligodendrocyte myelin glycoprotein / P23515*  / complex / reaction






 

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