ENSMUSG00000036634


Mus musculus

Features
Gene ID: ENSMUSG00000036634
  
Biological name :Mag
  
Synonyms : Mag / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20917
  
Possible biological names infered from orthology : myelin associated glycoprotein / P20916
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30899176
Gene end: 30914873
  
Corresponding Affymetrix probe sets: 10562152 (MoGene1.0st)   1460219_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139881
Ensembl peptide - ENSMUSP00000139861
Ensembl peptide - ENSMUSP00000140526
Ensembl peptide - ENSMUSP00000140578
Ensembl peptide - ENSMUSP00000041464
Ensembl peptide - ENSMUSP00000139564
NCBI entrez gene - 17136     See in Manteia.
MGI - MGI:96912
RefSeq - XM_017322008
RefSeq - NM_001346087
RefSeq - NM_001346088
RefSeq - NM_010758
RefSeq - XM_006539590
RefSeq - XM_006539591
RefSeq - XM_011250438
RefSeq - XM_011250439
RefSeq - XM_011250440
RefSeq - XM_011250441
RefSeq - XM_017322007
RefSeq Peptide - NP_034888
RefSeq Peptide - NP_001333013
RefSeq Peptide - NP_001333014
RefSeq Peptide - NP_001333015
RefSeq Peptide - NP_001333016
RefSeq Peptide - NP_001333017
swissprot - A0A087WRD6
swissprot - A0A087WPR1
swissprot - P20917
swissprot - Q3ZB60
swissprot - A0A087WPP5
Ensembl - ENSMUSG00000036634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 magENSDARG00000104023Danio rerio
 MAGENSG00000105695Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80ZE3 / Siglecg / Sialic acid-binding Ig-like lectin 10 / Q96RL6* / Q96LC7* / SIGLEC10* / SIGLEC11* / sialic acid binding Ig like lectin 11*ENSMUSG0000003046823
Q920G3 / Siglec5 / Sialic acid-binding Ig-like lectin 5 ENSMUSG0000003901321
Q91Y57 / Siglece / Sialic acid-binding Ig-like lectin 12 / Q9Y286* / Q9Y336* / Q9NYZ4* / Q96PQ1* / SIGLEC7* / SIGLEC8* / SIGLEC9* / SIGLEC12* / sialic acid binding Ig like lectin 7* / sial...ENSMUSG0000003047415
Cd33 / Q63994 / Myeloid cell surface antigen CD33 ENSMUSG0000000460913
Siglech / sialic acid binding Ig-like lectin H / CD33* / P20138* / CD33 molecule*ENSMUSG0000005150411


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0022010 central nervous system myelination IMP
 biological_processGO:0030517 negative regulation of axon extension ISS
 biological_processGO:0031643 positive regulation of myelination IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0033270 paranode region of axon IDA
 cellular_componentGO:0035749 myelin sheath adaxonal region IDA
 cellular_componentGO:0043209 myelin sheath ISO
 cellular_componentGO:0043218 compact myelin ISO
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097453 mesaxon IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:1905576 ganglioside GT1b binding IMP


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
Basigin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdktm1Tmu/Mdktm1Tmu,Ptntm1Tmu/Ptntm1Tmu
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Loxhd1mpc231H/Loxhd1mpc231H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Magtm1Mtg/Magtm1Mtg
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Magtm1Mtg/Magtm1Mtg,Ncam1tm1Cgn/Ncam1tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0012674 tomacula "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb]
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6N.129-Plp1tm1Kan

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6N.129-Plp1tm1Kan

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / complex / reaction
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / reaction / complex
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex / reaction
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex






 

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