ENSMUSG00000043811


Mus musculus

Features
Gene ID: ENSMUSG00000043811
  
Biological name :Rtn4r
  
Synonyms : Q99PI8 / Reticulon-4 receptor / Rtn4r
  
Possible biological names infered from orthology : Q9BZR6
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 18127642
Gene end: 18152408
  
Corresponding Affymetrix probe sets: 10434144 (MoGene1.0st)   1419732_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062924
NCBI entrez gene - 65079     See in Manteia.
MGI - MGI:2136886
RefSeq - NM_022982
RefSeq Peptide - NP_075358
swissprot - Q99PI8
Ensembl - ENSMUSG00000043811
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4rENSDARG00000090035Danio rerio
 ENSGALG00000007732Gallus gallus
 RTN4RENSG00000040608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K0S5 / Rtn4rl1 / Reticulon-4 receptor-like 1 / Q86UN2*ENSMUSG0000004528736
Q7M6Z0 / Rtn4rl2 / Reticulon-4 receptor-like 2 / Q86UN3*ENSMUSG0000005089635
Lrrc24 / Q8BHA1 / Leucine-rich repeat-containing protein 24 / Q50LG9* / leucine rich repeat containing 24*ENSMUSG0000003370722
Lrrc26 / Q91W20 / Leucine-rich repeat-containing protein 26 / Q2I0M4* / leucine rich repeat containing 26*ENSMUSG0000002696118
Lrtm2 / Q8BGX3 / Leucine-rich repeat and transmembrane domain-containing protein 2 / Q8N967* / leucine rich repeats and transmembrane domains 2*ENSMUSG0000005500316
Lrrc55 / Q3UY51 / Leucine-rich repeat-containing protein 55 / Q6ZSA7* / leucine rich repeat containing 55*ENSMUSG0000007522416
A2VDH3 / Lrrc38 / Leucine-rich repeat-containing protein 38 / Q5VT99* / leucine rich repeat containing 38*ENSMUSG0000002858416
Lrtm1 / Q8BXQ3 / Leucine-rich repeat and transmembrane domain-containing protein 1 / Q9HBL6* / leucine rich repeats and transmembrane domains 1*ENSMUSG0000004577615
Lrrc52 / Q5M8M9 / Leucine-rich repeat-containing protein 52 / Q8N7C0* / leucine rich repeat containing 52*ENSMUSG0000004048515


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0023041 neuronal signal transduction IDA
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0035374 chondroitin sulfate binding IDA
 molecular_functionGO:0038131 neuregulin receptor activity IDA
 molecular_functionGO:1905573 ganglioside GM1 binding IEA
 molecular_functionGO:1905576 ganglioside GT1b binding IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0003075 response to CNS ischemic injury 
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Ighmtm4Bgmn/Ighmtm4Bgmn
Genetic Background: involves: 129/Sv

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Notch3tm1.1Dwr/Notch3+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0004858 abnormal nervous system regeneration "changes in the ability or inability of healthy nervous system tissue to regenerate following injury or disease" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mboat7tm1a(KOMP)Wtsi/Mboat7tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Rtn4rtm2.2Stmr/Rtn4rtm2.2Stmr
Genetic Background: B6.Cg-Rtn4rtm2.2Stmr

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Crtac1tm1Kota/Crtac1tm1Kota,Rtn4rtm1Stmr/Rtn4rtm1Stmr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030013 improved central nervous system regeneration "faster or more complete regeneration of healthy central nervous system tissue following injury or disease" [] {comment="MGI:anna"}
Show

Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg,Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

Allelic Composition: Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

Allelic Composition: Ptprstm1Mtr/Ptprstm1Mtr,Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000036634 Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*  / reaction / complex
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / -
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / reaction / complex
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSMUSG00000020458 Rtn4 / Q99P72 / reticulon 4 / Q9NQC3*  / reaction / complex
 ENSMUSG00000049612 Omg / oligodendrocyte myelin glycoprotein / P23515*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr