ENSG00000040608


Homo sapiens

Features
Gene ID: ENSG00000040608
  
Biological name :RTN4R
  
Synonyms : Q9BZR6 / reticulon 4 receptor / RTN4R
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.21
Gene start: 20241415
Gene end: 20283246
  
Corresponding Affymetrix probe sets: 228550_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396872
Ensembl peptide - ENSP00000403535
Ensembl peptide - ENSP00000043402
NCBI entrez gene - 65078     See in Manteia.
OMIM - 605566
RefSeq - NM_023004
RefSeq Peptide - NP_075380
swissprot - Q9BZR6
swissprot - H7C0V4
swissprot - H7C215
Ensembl - ENSG00000040608
  
Related genetic diseases (OMIM): 181500 - {Schizophrenia, susceptibility to}, 181500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4rENSDARG00000090035Danio rerio
 ENSGALG00000007732Gallus gallus
 Rtn4rENSMUSG00000043811Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86UN2 / RTN4RL1 / reticulon 4 receptor like 1ENSG0000018592438
Q86UN3 / RTN4RL2 / reticulon 4 receptor like 2ENSG0000018690736
LRRC24 / Q50LG9 / leucine rich repeat containing 24ENSG0000025440223
LRRC26 / Q2I0M4 / leucine rich repeat containing 26ENSG0000018470919
LRRC38 / Q5VT99 / leucine rich repeat containing 38ENSG0000016249417
LRTM1 / Q9HBL6 / leucine rich repeats and transmembrane domains 1ENSG0000014477117
LRRC55 / Q6ZSA7 / leucine rich repeat containing 55ENSG0000018390816
LRTM2 / Q8N967 / leucine rich repeats and transmembrane domains 2ENSG0000016615916
LRRC52 / Q8N7C0 / leucine rich repeat containing 52ENSG0000016276315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0023041 neuronal signal transduction IEA
 biological_processGO:0030517 negative regulation of axon extension IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:0050771 negative regulation of axonogenesis TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IMP
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0035374 chondroitin sulfate binding IEA
 molecular_functionGO:0038131 neuregulin receptor activity IEA
 molecular_functionGO:1905573 ganglioside GM1 binding IDA
 molecular_functionGO:1905576 ganglioside GT1b binding IDA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141522 P52565 / ARHGDIA / Rho GDP dissociation inhibitor alpha  / complex / reaction
 ENSG00000040608 RTN4R / Q9BZR6 / reticulon 4 receptor  / -
 ENSG00000169783 LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1  / complex / reaction
 ENSG00000115310 RTN4 / Q9NQC3 / reticulon 4  / complex / reaction
 ENSG00000126861 OMG / P23515 / oligodendrocyte myelin glycoprotein  / reaction / complex
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000105695 MAG / P20916 / myelin associated glycoprotein  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction






 

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