ENSMUSG00000020458


Mus musculus

Features
Gene ID: ENSMUSG00000020458
  
Biological name :Rtn4
  
Synonyms : Q99P72 / reticulon 4 / Rtn4
  
Possible biological names infered from orthology : Q9NQC3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.3
Gene start: 29692947
Gene end: 29744331
  
Corresponding Affymetrix probe sets: 10374908 (MoGene1.0st)   1421116_a_at (Mouse Genome 430 2.0 Array)   1435284_at (Mouse Genome 430 2.0 Array)   1437224_at (Mouse Genome 430 2.0 Array)   1439650_at (Mouse Genome 430 2.0 Array)   1452649_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053754
Ensembl peptide - ENSMUSP00000077875
Ensembl peptide - ENSMUSP00000099905
Ensembl peptide - ENSMUSP00000099907
Ensembl peptide - ENSMUSP00000126413
Ensembl peptide - ENSMUSP00000099906
NCBI entrez gene - 68585     See in Manteia.
MGI - MGI:1915835
RefSeq - NM_194053
RefSeq - NM_024226
RefSeq - NM_194051
RefSeq - NM_194052
RefSeq - NM_194054
RefSeq Peptide - NP_077188
RefSeq Peptide - NP_918940
RefSeq Peptide - NP_918941
RefSeq Peptide - NP_918942
RefSeq Peptide - NP_918943
swissprot - Q78NS1
swissprot - Q8BH78
swissprot - Q8BHF5
swissprot - Q99P72
Ensembl - ENSMUSG00000020458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4aENSDARG00000044601Danio rerio
 rtn4bENSDARG00000104347Danio rerio
 RTN4ENSGALG00000029261Gallus gallus
 RTN4ENSG00000115310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rtn3 / Q9ES97 / Reticulon-3 / O95197*ENSMUSG0000002475820
Rtn1 / Q8K0T0 / reticulon 1 / Q16799*ENSMUSG0000002108720
Rtn2 / O70622 / reticulon 2 (Z-band associated protein) / O75298* / reticulon 2*ENSMUSG0000003040112


Protein motifs (from Interpro)
Interpro ID Name
 IPR003388  Reticulon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration ISO
 biological_processGO:0021801 cerebral cortex radial glia guided migration IMP
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030334 regulation of cell migration ISO
 biological_processGO:0030517 negative regulation of axon extension ISO
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation ISO
 biological_processGO:0048694 positive regulation of collateral sprouting of injured axon IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051292 nuclear pore complex assembly ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0051960 regulation of nervous system development IMP
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0071786 endoplasmic reticulum tubular network organization ISS
 biological_processGO:0071787 endoplasmic reticulum tubular network formation ISO
 biological_processGO:1903860 negative regulation of dendrite extension IMP
 biological_processGO:1905552 positive regulation of protein localization to endoplasmic reticulum ISO
 biological_processGO:1905580 positive regulation of ERBB3 signaling pathway ISO
 biological_processGO:1905943 negative regulation of formation of growth cone in injured axon IMP
 biological_processGO:1990809 endoplasmic reticulum tubular network membrane organization ISO
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve IMP
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0044294 dendritic growth cone IDA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network ISO
 cellular_componentGO:0098826 endoplasmic reticulum tubular network membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Rtn4tm3.1Matl/Rtn4tm3.1Matl
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003407 abnormal CNS regeneration "changes in the ability or inability of healthy central nervous system tissue to regenerate following injury or disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: B6.Cg-Nlgn3tm1Bros

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Gli3Mos1/Gli3+,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0030013 improved central nervous system regeneration "faster or more complete regeneration of healthy central nervous system tissue following injury or disease" [] {comment="MGI:anna"}
Show

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

Allelic Composition: Rtn4tm1Schw/Rtn4tm1Schw
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex / reaction
 ENSMUSG00000043811 Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*  / complex / reaction
 ENSMUSG00000049556 Lingo1 / Q9D1T0 / Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 / Q96FE5* / leucine rich repeat and Ig domain containing 1*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr