ENSDARG00000044601


Danio rerio

Features
Gene ID: ENSDARG00000044601
  
Biological name :rtn4a
  
Synonyms : reticulon 4a / rtn4a
  
Possible biological names infered from orthology : Q99P72 / Q9NQC3 / reticulon 4 / RTN4
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 6231012
Gene end: 6258451
  
Corresponding Affymetrix probe sets: Dr.24718.1.A1_at (Zebrafish Array)   NM_001079912_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000076390
Ensembl peptide - ENSDARP00000076404
Ensembl peptide - ENSDARP00000106859
Ensembl peptide - ENSDARP00000108083
NCBI entrez gene - 447816     See in Manteia.
RefSeq - NM_001201446
RefSeq - NM_001079912
RefSeq Peptide - NP_001188375
RefSeq Peptide - NP_001073381
swissprot - Q4G5W0
swissprot - Q4G5W2
swissprot - Q4G5V9
swissprot - F1QT89
ZFIN ID - ZDB-GENE-030710-1
Ensembl - ENSDARG00000044601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RTN4ENSGALG00000029261Gallus gallus
 RTN4ENSG00000115310Homo sapiens
 Rtn4ENSMUSG00000020458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rtn1b / reticulon 1b / RTN1* / Q16799* / Q8K0T0* / reticulon 1*ENSDARG0000002114344
rtn1a / reticulon 1a / RTN1* / Q16799* / Q8K0T0* / reticulon 1*ENSDARG0000000649742
rtn4b / reticulon 4b / RTN4* / Q9NQC3* / reticulon 4*ENSDARG0000010434739
rtn3 / reticulon 3 / O95197* / Q9ES97*ENSDARG0000009134834
rtn2a / reticulon 2a / RTN2* / O75298* / O70622* / reticulon 2* / reticulon 2 (Z-band associated protein)*ENSDARG0000001608824
rtn2b / reticulon 2b / RTN2* / O75298* / O70622* / reticulon 2* / reticulon 2 (Z-band associated protein)*ENSDARG0000005702721


Protein motifs (from Interpro)
Interpro ID Name
 IPR003388  Reticulon


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IBA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021554 optic nerve development IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0048916 posterior lateral line development IGI
 biological_processGO:0048922 posterior lateral line neuromast deposition IGI
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IMP
 biological_processGO:0060231 mesenchymal to epithelial transition IGI
 biological_processGO:0061053 somite development IGI
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000109 forebrain forebrain decreased size , abnormal
forebrain flattened , abnormal
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 ZFA:0000152 retina retina has fewer parts of type retinal ganglion cell , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve decreased length , abnormal
posterior lateral line nerve defasciculated , abnormal
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 ZFA:0000243 neuromast neuromast displaced , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II has fewer parts of type retinal ganglion cell axon, abnormal
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 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
optic tectum has fewer parts of type retinal ganglion cell neuron projection, abnormal
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 ZFA:0000641 cranial nerve cranial nerve morphology , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head altered number of neuromast , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
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 ZFA:0001678 immature eye immature eye decreased size , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon guidance process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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