ENSDARG00000104347


Danio rerio

Features
Gene ID: ENSDARG00000104347
  
Biological name :rtn4b
  
Synonyms : reticulon 4b / rtn4b
  
Possible biological names infered from orthology : Q99P72 / Q9NQC3 / reticulon 4 / RTN4
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 216320
Gene end: 226393
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131624
Ensembl peptide - ENSDARP00000140345
Ensembl peptide - ENSDARP00000136327
Ensembl peptide - ENSDARP00000135986
Ensembl peptide - ENSDARP00000131948
NCBI entrez gene - 678586     See in Manteia.
RefSeq - NM_001040335
RefSeq Peptide - NP_001035425
swissprot - A0A0R4IL48
swissprot - A0A0R4IF59
swissprot - A0A0R4ICW0
swissprot - A0A0R4ISY7
swissprot - A0A0R4INK8
ZFIN ID - ZDB-GENE-030710-2
Ensembl - ENSDARG00000104347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RTN4ENSGALG00000029261Gallus gallus
 RTN4ENSG00000115310Homo sapiens
 Rtn4ENSMUSG00000020458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rtn1a / reticulon 1a / RTN1* / Q16799* / Q8K0T0* / reticulon 1*ENSDARG0000000649718
rtn1b / reticulon 1b / RTN1* / Q16799* / Q8K0T0* / reticulon 1*ENSDARG0000002114318
rtn4a / reticulon 4a / RTN4* / Q99P72* / Q9NQC3* / reticulon 4*ENSDARG0000004460114
rtn3 / reticulon 3 / O95197* / Q9ES97*ENSDARG0000009134811
rtn2a / reticulon 2a / RTN2* / O75298* / O70622* / reticulon 2* / reticulon 2 (Z-band associated protein)*ENSDARG000000160887
rtn2b / reticulon 2b / RTN2* / O75298* / O70622* / reticulon 2* / reticulon 2 (Z-band associated protein)*ENSDARG000000570277


Protein motifs (from Interpro)
Interpro ID Name
 IPR003388  Reticulon
 IPR003882  Pistil-specific extensin-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0021554 optic nerve development IMP
 biological_processGO:0021557 oculomotor nerve development IMP
 biological_processGO:0021558 trochlear nerve development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048884 neuromast development IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005199 structural constituent of cell wall IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
Show

 ZFA:0000022 floor plate floor plate anterior region deformed , abnormal
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 ZFA:0000032 hypothalamus hypothalamus deformed , abnormal
Show

 ZFA:0000048 olfactory placode olfactory placode morphology , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has fewer parts of type motor neuron , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000109 forebrain forebrain deformed , abnormal
forebrain decreased size , abnormal
forebrain flattened , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle deformed , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
notochord curved , abnormal
Show

 ZFA:0000152 retina retina has fewer parts of type retinal ganglion cell , abnormal
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 ZFA:0000243 neuromast neuromast displaced , abnormal
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 ZFA:0000405 cranial nerve III cranial nerve III absent , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II immature , abnormal
cranial nerve II axon regeneration disrupted , abnormal
cranial nerve II has fewer parts of type retinal ganglion cell axon, abnormal
Show

 ZFA:0000445 optic tectum optic tectum mislocalised anteriorly , abnormal
optic tectum decreased size , abnormal
optic tectum has fewer parts of type retinal ganglion cell neuron projection, abnormal
Show

 ZFA:0000600 cranial nerve IV cranial nerve IV absent , abnormal
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 ZFA:0000653 dorsal thalamus dorsal thalamus deformed , abnormal
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 ZFA:0001058 caudal fin caudal fin curved ventral , abnormal
caudal fin decreased thickness , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head altered number of neuromast , abnormal
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 ZFA:0001161 pectoral fin pectoral fin aplastic/hypoplastic , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch absent , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 absent , abnormal
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 ZFA:0001655 pericardial cavity pericardial cavity inflated , abnormal
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 ZFA:0001678 immature eye immature eye decreased size , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell immature , abnormal
retinal ganglion cell neuron projection immature , abnormal
retinal ganglion cell axon guidance process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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