ENSMUSG00000030468


Mus musculus

Features
Gene ID: ENSMUSG00000030468
  
Biological name :Siglecg
  
Synonyms : Q80ZE3 / Sialic acid-binding Ig-like lectin 10 / Siglecg
  
Possible biological names infered from orthology : Q96LC7 / Q96RL6 / sialic acid binding Ig like lectin 11 / SIGLEC10 / SIGLEC11
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 43408204
Gene end: 43418358
  
Corresponding Affymetrix probe sets: 10552380 (MoGene1.0st)   1435955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005592
NCBI entrez gene - 243958     See in Manteia.
MGI - MGI:2443630
RefSeq - XM_006540862
RefSeq - NM_172900
RefSeq - XM_006540860
RefSeq - XM_006540861
RefSeq Peptide - NP_766488
swissprot - Q80ZE3
Ensembl - ENSMUSG00000030468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-24p1.7ENSDARG00000089404Danio rerio
 Q96LC7ENSG00000142512Homo sapiens
 Q96RL6ENSG00000161640Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q920G3 / Siglec5 / Sialic acid-binding Ig-like lectin 5 ENSMUSG0000003901331
Q91Y57 / Siglece / Sialic acid-binding Ig-like lectin 12 / Q9Y286* / Q9Y336* / Q9NYZ4* / Q96PQ1* / SIGLEC7* / SIGLEC8* / SIGLEC9* / SIGLEC12* / sialic acid binding Ig like lectin 7* / sial...ENSMUSG0000003047426
Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*ENSMUSG0000003663420
Cd33 / Q63994 / Myeloid cell surface antigen CD33 ENSMUSG0000000460915
Siglech / sialic acid binding Ig-like lectin H / CD33* / P20138* / CD33 molecule*ENSMUSG0000005150415


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0106015 negative regulation of inflammatory response to wounding ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019902 phosphatase binding ISO
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042169 SH2 domain binding ISO


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Siglecgtm1Yliu/Siglecgtm1Yliu
Genetic Background: C57BL/6-Siglecgtm1Yliu

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Siglecgtm1Yliu/Siglecgtm1Yliu
Genetic Background: C57BL/6-Siglecgtm1Yliu

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Siglecgtm1Yliu/Siglecgtm1Yliu
Genetic Background: C57BL/6-Siglecgtm1Yliu

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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