ENSMUSG00000051504


Mus musculus

Features
Gene ID: ENSMUSG00000051504
  
Biological name :Siglech
  
Synonyms : sialic acid binding Ig-like lectin H / Siglech
  
Possible biological names infered from orthology : CD33 / CD33 molecule / P20138
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B5
Gene start: 55768178
Gene end: 55778925
  
Corresponding Affymetrix probe sets: 10553559 (MoGene1.0st)   1436131_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130943
Ensembl peptide - ENSMUSP00000130632
Ensembl peptide - ENSMUSP00000134017
Ensembl peptide - ENSMUSP00000134721
Ensembl peptide - ENSMUSP00000058875
Ensembl peptide - ENSMUSP00000091920
Ensembl peptide - ENSMUSP00000113665
Ensembl peptide - ENSMUSP00000122697
NCBI entrez gene - 233274     See in Manteia.
MGI - MGI:2443256
RefSeq - XM_017322171
RefSeq - NM_178706
RefSeq - XM_006540827
RefSeq - XM_006540828
RefSeq - XM_006540830
RefSeq - XM_006540831
RefSeq - XM_006540832
RefSeq - XM_011250857
RefSeq - XM_011250858
RefSeq - XM_011250859
RefSeq - NM_001310738
RefSeq - NM_001310740
RefSeq Peptide - NP_001297669
RefSeq Peptide - NP_848821
RefSeq Peptide - NP_001297667
swissprot - B7ZMQ6
swissprot - D6RFU8
swissprot - Q4QQK7
swissprot - B7ZMQ5
swissprot - G3UYB4
swissprot - G3X9N0
Ensembl - ENSMUSG00000051504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-24p1.7ENSDARG00000089404Danio rerio
 CD33ENSG00000105383Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q920G3 / Siglec5 / Sialic acid-binding Ig-like lectin 5 ENSMUSG0000003901346
Cd33 / Q63994 / Myeloid cell surface antigen CD33 ENSMUSG0000000460943
Q91Y57 / Siglece / Sialic acid-binding Ig-like lectin 12 / Q9Y286* / Q9Y336* / Q9NYZ4* / Q96PQ1* / SIGLEC7* / SIGLEC8* / SIGLEC9* / SIGLEC12* / sialic acid binding Ig like lectin 7* / sial...ENSMUSG0000003047441
Q80ZE3 / Siglecg / Sialic acid-binding Ig-like lectin 10 / Q96RL6* / Q96LC7* / SIGLEC10* / SIGLEC11* / sialic acid binding Ig like lectin 11*ENSMUSG0000003046833
Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*ENSMUSG0000003663420


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0038024 cargo receptor activity IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0008124 decreased plasmacytoid dendritic cell number "reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Siglechtm1.1Cln/Siglech+,Tg(CLEC4C-HBEGF)956Cln/0
Genetic Background: involves: C57BL/6

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0009786 decreased susceptibility to infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Tsc22d3tm1Ric/Y,Tg(Ddx4-cre)1Dcas/?
Genetic Background: involves: C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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