ENSG00000062524


Homo sapiens

Features
Gene ID: ENSG00000062524
  
Biological name :LTK
  
Synonyms : leukocyte receptor tyrosine kinase / LTK / P29376
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 41503638
Gene end: 41513887
  
Corresponding Affymetrix probe sets: 207106_s_at (Human Genome U133 Plus 2.0 Array)   217184_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263800
Ensembl peptide - ENSP00000347293
Ensembl peptide - ENSP00000392196
Ensembl peptide - ENSP00000458111
NCBI entrez gene - 4058     See in Manteia.
OMIM - 151520
RefSeq - XM_017022183
RefSeq - NM_001135685
RefSeq - NM_002344
RefSeq - NM_206961
RefSeq - XM_011521556
RefSeq - XM_011521557
RefSeq - XM_017022181
RefSeq - XM_017022182
RefSeq Peptide - NP_001129157
RefSeq Peptide - NP_002335
RefSeq Peptide - NP_996844
swissprot - H3BVG6
swissprot - P29376
Ensembl - ENSG00000062524
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ltkENSDARG00000042861Danio rerio
 LTKENSGALG00000008615Gallus gallus
 LtkENSMUSG00000027297Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109455
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793623
INSR / P06213 / insulin receptorENSG0000017110522
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044322
INSRR / P14616 / insulin receptor related receptorENSG0000002764421
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548317
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840016
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805316
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030416
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053816
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265516
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907116
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458015
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IDA
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0071300 cellular response to retinoic acid IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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