ENSG00000171094


Homo sapiens

Features
Gene ID: ENSG00000171094
  
Biological name :ALK
  
Synonyms : ALK / ALK receptor tyrosine kinase / Q9UM73
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.1
Gene start: 29192774
Gene end: 29921566
  
Corresponding Affymetrix probe sets: 208211_s_at (Human Genome U133 Plus 2.0 Array)   208212_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387488
Ensembl peptide - ENSP00000493203
Ensembl peptide - ENSP00000482733
Ensembl peptide - ENSP00000414027
Ensembl peptide - ENSP00000373700
NCBI entrez gene - 238     See in Manteia.
OMIM - 105590
RefSeq - NM_004304
RefSeq - NM_001353765
RefSeq Peptide - NP_001340694
RefSeq Peptide - NP_004295
swissprot - E7EPW7
swissprot - Q9UM73
swissprot - A0A0K2YUJ3
swissprot - A0A087WZL3
swissprot - H7BZ33
Ensembl - ENSG00000171094
  
Related genetic diseases (OMIM): 613014 - {Neuroblastoma, susceptibility to, 3}, 613014
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkENSDARG00000095833Danio rerio
 ENSGALG00000009034Gallus gallus
 AlkENSMUSG00000055471Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252429
INSR / P06213 / insulin receptorENSG0000017110516
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793616
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044316
INSRR / P14616 / insulin receptor related receptorENSG0000002764414
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840011
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805311
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053811
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548311
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030411
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273310
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458010
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907110
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG000001126559


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000998  MAM domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR026830  ALK tyrosine kinase receptor
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030534 adult behavior IEA
 biological_processGO:0036269 swimming behavior IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway IEA
 biological_processGO:0090648 response to environmental enrichment IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0004375 Neoplasia of the nervous system 
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 HP:0011976 Elevated urinary catecholamines "An increased concentration of `catecholamine` (CHEBI:33567) in the urine." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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