ENSG00000112655


Homo sapiens

Features
Gene ID: ENSG00000112655
  
Biological name :PTK7
  
Synonyms : protein tyrosine kinase 7 (inactive) / PTK7 / Q13308
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 43076268
Gene end: 43161719
  
Corresponding Affymetrix probe sets: 1555324_at (Human Genome U133 Plus 2.0 Array)   207011_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420186
Ensembl peptide - ENSP00000420165
Ensembl peptide - ENSP00000420322
Ensembl peptide - ENSP00000420765
Ensembl peptide - ENSP00000230418
Ensembl peptide - ENSP00000230419
Ensembl peptide - ENSP00000325462
Ensembl peptide - ENSP00000325992
Ensembl peptide - ENSP00000326029
Ensembl peptide - ENSP00000417607
Ensembl peptide - ENSP00000418386
Ensembl peptide - ENSP00000418462
Ensembl peptide - ENSP00000418545
Ensembl peptide - ENSP00000418754
Ensembl peptide - ENSP00000419037
Ensembl peptide - ENSP00000419096
NCBI entrez gene - 5754     See in Manteia.
OMIM - 601890
RefSeq - XM_011514766
RefSeq - NM_001270398
RefSeq - NM_002821
RefSeq - NM_152880
RefSeq - NM_152881
RefSeq - NM_152882
RefSeq - XM_011514765
RefSeq Peptide - NP_690620
RefSeq Peptide - NP_001257327
RefSeq Peptide - NP_002812
RefSeq Peptide - NP_690619
RefSeq Peptide - NP_690621
swissprot - F8WCI7
swissprot - F8WDG7
swissprot - H0Y889
swissprot - H0Y8F1
swissprot - H7C5L0
swissprot - H7C4X3
swissprot - Q13308
swissprot - Q86X91
swissprot - C9J9E8
swissprot - C9JQR6
Ensembl - ENSG00000112655
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk7aENSDARG00000011863Danio rerio
 PTK7ENSGALG00000008609Gallus gallus
 Ptk7ENSMUSG00000023972Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793626
INSRR / P14616 / insulin receptor related receptorENSG0000002764416
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044316
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030415
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053815
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840015
INSR / P06213 / insulin receptorENSG0000017110515
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109414
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805314
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458013
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273313
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907113
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252413
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033592  Inactive tyrosine-protein kinase 7
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0003401 axis elongation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IEA
 biological_processGO:0060026 convergent extension IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060484 lung-associated mesenchyme development IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr